This course familiarizes students with the novel concepts being used to revamp regulatory toxicology in response to a breakthrough National Research Council Report “Toxicity Testing in the 21st Century: A Vision and a Strategy.” We present the latest developments in the field of toxicology—the shift from animal testing toward human relevant, high content, high-throughput integrative testing strategies. Active programs from EPA, NIH, and the global scientific community illustrate the dynamics of safety sciences.
oferecido por
Universidade Johns Hopkins
Programa - O que você aprenderá com este curso
Semana
175 horas para concluir
Module 1
This model will give you a broad introduction to the Toxicology 21st century (Tox21c) field and familiarize you with the main document, which summarize the main ideas and principles of Tox21c.
10 vídeos (Total 121 mín.), 3 leituras, 1 teste
10 videos
Course Introduction16min
Introduction49s
Center for Alternatives to Animal Testing4min
Toxicology of the Fifteenth to Twentieth Centuries15min
Toxicology for the Twenty-First Century15min
Historical Perspective17min
The First Report: Toxicity Testing for Assessment of Environmental Agents11min
The Second Report: Toxicity Testing in the 21st Century: A Vision and A Strategy Vision and Its Components22min
The Second Report: Toxicity Testing in the 21st Century: A vision and A Strategy Implementation13min
3 leituras
useful links20min
supporting reading material10min
Supporting reading material10min
1 exercício prático
Module 1 Quizs
Semana
25 horas para concluir
Module 2
This module will discuss how ToxCast and Tox21 technologies can be used in practice. The US EPA Endocrine Disruptor Screening Program will be discussed in detail and we will demonstrate how the ToxCast platform replaced in vivo tiered approaches in EDSP and, thus, acelerate the process of . In the second lesson of this module, the development of in silico models for toxicity testing will be discussed.
10 vídeos (Total 119 mín.), 4 leituras, 2 testes
10 videos
Adverse Outcome Pathways (AOPs)10min
Exposure-Based Chemical Prioritization13min
ER Bioactivity Model16min
US EPA Endocrine Disruptor Screening Program (EDSP)17min
Modeling of Hazard and Organ Manifestation11min
Building a Signature for Vascular Disruption10min
Testing the Vascular Disruption Signature8min
Virtual Tissue Model: Vascular Development12min
Functional Vascular Development Assays16min
4 leituras
Supporting Reading Material10min
Useful links10min
Supporting Reading Material10min
Useful links10min
1 exercício prático
Module 2 Quiz8min
Semana
33 horas para concluir
Module 3
This module will familiarize you with the Human Toxome Project run by Johns Hopkins University in collaboration with several university, industry, and research agencies. Omics technologies, their advantages and disadvantages, as well as concepts of Adverse Outcome Pathways (AOP) and Pathways of Toxicity (PoT) will be discussed.
11 vídeos (Total 126 mín.), 2 leituras, 1 teste
11 videos
Mechanistic Toxicology and Pathway Mapping at the Basics of 21st Century Toxicology16min
The Concept of the Human Toxome Project21min
Concept and Tool Devlopment11min
Progress7min
Conclusions and Prospectives8min
Introduction - What Is a Pathway of Toxicity, and Why Do We Need Them?6min
Omics Technologies and High-Throughput Data11min
Interpreting Omics Data11min
PoT Examples and Conclusions15min
Pathways of Toxicity and Adverse Outcome Pathways (AOPs)13min
2 leituras
Supporting reading materials10min
Supporting reading material10min
1 exercício prático
Module 3 Quiz8min
Semana
44 horas para concluir
Module 4
The first lesson in this module will explain the concept of read-across, why it is important for regulatory risk assessment, and how it can be implemented by industry in response to REACH legislation. The organotypic cultures lesson will teach you about existing in vitro cell-based models starting from simple monolayer cultures of cell lines and ending with complex combined organ-on-a-chip and human-on-a-chip approaches.
15 vídeos (Total 148 mín.), 3 leituras, 2 testes
15 videos
The Concept of Toxicological (Biological) Pathways, e.g., “Adverse Outcome Pathways,” Is the Basis of Predictive Toxicology5min
Introduction to the OECD AOP Framework10min
Building, Evaluating, and Using AOPs in Safety Decisions6min
Online Tools Available to Everyone, Including an Online AOP Course4min
Welcome to Module 42min
Introduction to Read-Across18min
Good Read-Across Practice21min
Supporting Read-Across with Biological Data12min
Creating a Database of Toxicity12min
Creating an Automated Tool for Read-Across9min
Paradigm Shift in Toxicology7min
2D In Vitro Cell Culture8min
3D In Vitro Cell Cultures8min
Organ-on-a-Chip11min
3 leituras
Supporting reading material10min
Supporting reading material10min
Useful links10min
2 exercícios práticos
Module 4 Quiz8min
Mid-term exam44min
1 hora para concluir
Module 5
This module will teach you the role of miRNA and epigenetics in toxicology and environmental health.
6 vídeos (Total 41 mín.), 1 leitura, 1 teste
6 videos
MicroRNA and Epigenetics4min
Epigenetics and Environment6min
MicroRNA: Biogenesis and Functions11min
Role of MicroRNA in Development6min
MicroRNA in Toxicology9min
1 leituras
Supporting reading material10min
1 exercício prático
Module 5 Quiz8min
4.7
8 avaliaçõesPrincipais avaliações do Toxicology 21: Scientific Applications
Very nicely designed course. The instructors offer an excellent and easy to understand overview of a range of promising Tox21 tools and approaches using good examples and illustrations.
A very well-taught course with lots of useful information. I highly recommend it.
Instrutores
Lena Smirnova
Research AssociateCenter for Alternatives to Animal Testing
Thomas Hartung
ProfessorEnvironmental Health and Engineering
Sobre Universidade Johns Hopkins
The mission of The Johns Hopkins University is to educate its students and cultivate their capacity for life-long learning, to foster independent and original research, and to bring the benefits of discovery to the world.
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