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Do curso por Johns Hopkins University

Toxicology 21: Scientific Applications

14 classificações

Johns Hopkins University

Toxicology 21: Scientific Applications

14 classificações

This course familiarizes students with the novel concepts being used to revamp regulatory toxicology in response to a breakthrough National Research Council Report “Toxicity Testing in the 21st Century: A Vision and a Strategy.” We present the latest developments in the field of toxicology—the shift from animal testing toward human relevant, high content, high-throughput integrative testing strategies. Active programs from EPA, NIH, and the global scientific community illustrate the dynamics of safety sciences.

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Module 7

In this lesson you will learn about integrated testing strategies and how they differ from individual tests or test batteries. Also a wrap-up lesson "beyond chemical" will summaries your knowledge from this course and give a out-look for further directions in the field of alternatives to animal testing.

Welcome to Module 73:09

Why Integrated Testing Strategies?5:41

What is an Integrated Testing Strategy?16:23

How to Compose Integrated Testing Strategies36:30

Strategies for Integrated Testing Strategies6:12

Quality Assurance of integrated Testing Strategies7:09

Conheça os instrutores

Lena Smirnova
Research Associate
Center for Alternatives to Animal Testing
Thomas Hartung
Professor
Environmental Health and Engineering

Hello! Welcome to another module.

Our first lesson is going to talk about why sometimes one plus one can be three.

This means, we're going to talk about integrated testing strategies,

which means we're using more than one test to inform us.

And this means that you believe that very often,

a combination of tests is more powerful than any of these tests alone.

Imagine simply one of the tests is

big screening test for we can test lots of substance for little money even if imprecise.

Then we use a second test which could be more

selective and identifies among the positives,

which are the real positives.

We will learn some other explanations how tests are being

combined and why one plus one is more than three,

and one plus one plus one is more than four.

So, it is something which is interesting concept enriching our toxicological toolbox.

Because so far, as we learn,

it was mainly a standalone test which we use one big test to do it all.

The lesson on toxicology for the 21st century

beyond chemicals is a perspective because toxicology for the 21st century,

as you will now know,

after the various lessons you have followed so far is

something which was developed around environmental chemicals.

Environmental chemicals are a specific case which means these

are substances which are often around already for many decades

where we have a backlog which is tremendous with respect to testing and where we have to

handle some hope of this relatively crude methodologies what is payable,

so we actually get to handle on the most critical substances.

However, these drugs, these pesticides,

these are very well tested substances,

however they've been tested with methods which are coming into doubt increasingly.

And also here, the concept of toxicology for the 21st century is with

this robotized testing with the computational methodologies with the Omics technologies,

with the integrated testing strategies has something to offer.

So, we will discuss how pharmacological,

pharmaceutical research can benefit of these approaches how the analysis of

pesticides might be done more efficiently using

less animals combining various information sources and others.

So, I hope you will understand, at the same time,

that this perspective is only showing you what is at the moment in

the beginning that these other areas are taking up these developments

and are suddenly learning from

environmental Toxicology which has not been in

the foreground of development of our science so far.

So with this lecture,

I hope you will have a more complete view on what the future might bring. Thanks a lot.

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