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Evidence-based Toxicology

Universidade Johns Hopkins

Informações sobre o curso

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Welcome to the Evidence-based Toxicology (EBT) course. In medicine and healthcare, evidence-based medicine has revolutionized the way that information is evaluated transparently and objectively. Over the past ten years, a movement in North America and Europe has attempted to translate this revolution to the field of toxicology.
The Center for Alternatives to Animal Testing (CAAT) within the department of Environmental Health and Engineering at the Johns Hopkins Bloomberg School of Public Health hosts the first chair for EBT and the secretariat for the EBT Collaboration on both sides of the Atlantic. Based on the Cochrane Collaboration in Evidence-based Medicine, the EBT Collaboration was established at the CAAT to foster the development of a process for quality assurance of new toxicity tests for the assessment of safety in humans and the environment.
Regulatory safety sciences have undergone remarkably little change in the past fifty years. At the same time, our knowledge in the life sciences is doubling about every seven years. Systematic review and related evidence-based approaches are beginning to be adapted by regulatory agencies like the Environment Protection Agency (EPA), the European Food Safety Authority (EFSA), and the US National Toxicology Program. They provide transparent, objective, and consistent tools to identify, select, appraise, and extract evidence across studies. 
This course will showcase these emerging efforts and address opportunities and challenges to the expanded use of these tools within toxicology.

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100% on-line

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Nível iniciante

Aprox. 20 horas para completar

Inglês

Legendas: Francês, Portuguese (European), Russo, Inglês, Espanhol

Prazos flexíveis

Redefinir os prazos de acordo com sua programação.

Certificados compartilháveis

Tenha o certificado após a conclusão

100% on-line

Comece imediatamente e aprenda em seu próprio cronograma.

Nível iniciante

Aprox. 20 horas para completar

Inglês

Legendas: Francês, Portuguese (European), Russo, Inglês, Espanhol

Instrutores

Classificação do instrutor

4,71/5 (28 classificações)

Thomas Hartung

Professor

Environmental Health and Engineering

13.247 aprendizes

2 Cursos

Lena Smirnova

Research Associate

Center for Alternatives to Animal Testing

13.247 aprendizes

2 Cursos

oferecido por

Universidade Johns Hopkins

The mission of The Johns Hopkins University is to educate its students and cultivate their capacity for life-long learning, to foster independent and original research, and to bring the benefits of discovery to the world.

Programa - O que você aprenderá com este curso

Semana

Semana 1

2 horas para concluir

Introduction & Shortcomings of Current Approaches

This module introduces you to the course, outlines the shortcomings of current toxicity testing approaches, and shows how EBT can help to overcome these shortcomings.

2 horas para concluir

9 vídeos (Total 66 mín.), 3 leituras, 1 teste

9 videos

Welcome3min

Introduction to the Course14min

Introduction5min

Shortcoming No. 1: Narrative Reviews7min

Shortcoming No. 2: Bias in Reviews7min

Shortcoming No. 3: Evidence Writing4min

Shortcoming No. 4: External Validity10min

Shortcoming No. 5: Assessing New Methods5min

Shortcoming No. 6: Inadequate Reporting7min

3 leituras

Letter to Learners10min

Course Learning Objectives10min

Supporting reading10min

1 exercício prático

Practice Quiz 130min

Semana

Semana 2

3 horas para concluir

History and Causation

This module explains how evidence-based toxicology originated and describes the driving forces for the initiative. In the second lesson, you will learn how to distinguish between correlation and causation as well as the main problems with drawing conclusions on the basis of correlations. The Bradford Hill criteria are introduced, along with examples for each criterion. You will also learn about mechanistic toxicology and mechanistic validation.

3 horas para concluir

11 vídeos (Total 138 mín.), 2 leituras, 1 teste

11 videos

Welcome to Module 21min

Personal First Exposures to Evidence-Based Medicine21min

The Start of EBT16min

The First Conference 2007 to the Start of the EBT Collaboration 201114min

The Evidence-Based Toxicology Collaboration (EBTC)13min

Introduction Causation vs. Correlation18min

The Hill Principles of Epidemiology and their Relation to Toxicology16min

The Problem of Causation in Toxicology16min

Biomarker Concept in Mechanistic Toxicology4min

Mechanistic Validation4min

The Future of Causation in Complex Systems9min

2 leituras

Supporting reading10min

1 exercício prático

Practice Quiz 230min

Semana

Semana 3

3 horas para concluir

Systematic Review and Meta-Analysis

This module shows how to perform systematic reviews and meta-analyses. You will learn the history of both methods and will receive step-by-step instructions on how to perform systematic reviews and meta-analyses using examples from the research activities of the instructors.

3 horas para concluir

8 vídeos (Total 101 mín.), 2 leituras, 2 testes

8 videos

Welcome to Module 33min

Systematic Reviews: Definition and Principles26min

Systematic Reviews - Protocol Development15min

Systematic Reviews - Protocol Development (Part 2)19min

History5min

Meta-analysis Guidelines7min

Meta-analysis Protocol, Part 110min

Meta-analysis Protocol, Part 212min

2 leituras

Supporting reading10min

2 exercícios práticos

Practice Quiz 330min

Mid-course exam30min

Semana

Semana 4

2 horas para concluir

Risk of Bias & Application to Test Methods Comparison

This module teaches you about possible biases that can be introduced at different stages of research. Each bias is explained with examples, including solutions for overcoming those biases. The second lesson covers systematic review of the zebrafish embryotoxicity test as a case study conducted by the Evidence-based Toxicology Collaboration (EBTC). You will go through all of the steps of the systematic review again to imprint the knowledge from module 3, but this systematic review will be related to a toxicological method.

2 horas para concluir

8 vídeos (Total 94 mín.), 2 leituras, 1 teste

8 videos

Welcome to Module 43min

Introduction to Risk of Bias Concept in Critical Appraisal of Studies26min

Examples for Risk of Bias Tools 1: Cochrane Collboration4min

Examples for Risk of Bias Tools 2: SYRCLE's RoB Tool5min

Examples of Risk of Bias Tools 3: National Institute for Environmental Health Sciences (NIEHS) - OHAT12min

Quality Assessment in Evidence-Based Toxicology7min

Evidence-Based Toxicology (EBT) and Evidence-Based Toxicology Collaboration (EBTC)11min

Zebrafish Systematic Review22min

2 leituras

Supporting reading10min

1 exercício prático

Practice Quiz 410min

Semana

Semana 5

3 horas para concluir

Quality Assurance, Good Practices, and Validation

Quality control is a very important aspect of not only modern toxicology but the entirety of life sciences. The first lesson in this module demonstrates the importance of performing quality control on your experiments. The second lesson is connected with the first one because validation of an alternative method requires highly standardized protocols and quality control at each step. This lesson teaches you different aspects of alternatives methods validation, how to perform classical validation, its pitfalls, and strategies to overcome them.

3 horas para concluir

10 vídeos (Total 140 mín.), 2 leituras, 1 teste

10 videos

Welcome to Module 52min

The Concepts of Quality Assurance (QA) and Good Practice (GP)14min

Good Practice22min

Quality Assurance12min

Importance of GP and QA in EBT5min

The Evolution of Validation of Alternative Methods29min

The Traditional Validation Process26min

Example of a Validation Study: Skin Irritation9min

Developments in the Validation Area6min

Validation and Tox-21c/EBT11min

2 leituras

Supporting reading10min

1 exercício prático

Practice Quiz 530min

Semana

Semana 6

3 horas para concluir

Biometrical Tools & Future Perspectives

Evidence-based toxicology requires some knowledge of bioinformatics. The first lesson in the module teaches you some biostatistical tools you can apply when analyzing predectivity, specificity, and sensitivity of a method. You will also learn how to identify biases in a study with the help of bioinformatics. Evidence-based principles can be applied to every question you might have, even to which pizza to order tonight. You will learn the difference between eminence-based vs. evidence-based approaches. You will learn what is driving the lack of reproducibility and how evidence-based approaches should help to overcome the reproducibility crisis in science, which is explained with examples of experimental design, wrong models, poor quality of the cell cultures, etc.

3 horas para concluir

8 vídeos (Total 98 mín.), 1 leitura, 2 testes

8 videos

Welcome to Module 64min

Why We Need Biometry/Statistics in Evidence-Based Toxicology9min

Statistics and Bioinformatics Applied in Evidence-Based Approaches I11min

Statistics and Bioinformatics Applied in Evidence-Based Approaches II18min

Risk and Bias and Its Impact on Evidence-Based Approaches12min

Evidence-Based Is a More Rigorous Scientific Approach to Anything4min

The Reproducibility Crisis in Science25min

Where Is Evidence-Based Toxicology (EBT) and What Are The Next Steps?11min

1 leituras

Supporting reading10min

2 exercícios práticos

Practice quiz 630min

Final exam30min

Semana

Semana 7

2 horas para concluir

Summative Assessment - Systematic Review Assignment

The final week of the course is devoted to completing the Systematic Review Assignment. You will use SysRev to review at least 20 abstracts, apply inclusion and exclusion criteria, render decisions, and resolve conflicts with other reviewers.

2 horas para concluir

1 leitura

Avaliações

4.7

21 avaliações

5 stars
77,31%
4 stars
17,52%
3 stars
4,12%
2 stars
1,03%

Principais avaliações do EVIDENCE-BASED TOXICOLOGY

por DJ25 de mai de 2020

Thanks for the opportunity to be part of those who will benefit from their awesome course.

por NF31 de jul de 2021

Excellent, it has given me a very clear and complete vision.gave me a very clear and complete picture.

por EE5 de abr de 2019

Surprisingly very informative and detailed Course. Thanks for the load of information given.

por HH4 de jul de 2020

Quite informative and exposed me to a whole new horizon in the ever blooming world of toxicology. I would like to thank Dr. Thomas Hartung and his team at John Hopkins for making this possible!

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Evidence-based Toxicology

Evidence-based Toxicology

Informações sobre o curso