In previous courses in the Specialization, we have discussed how to sequence and compare genomes. This course will cover advanced topics in finding mutations lurking within DNA and proteins.
Este curso faz parte do Programa de cursos integrados Bioinformática
Decifrando Mutações no DNA e nas Proteínas (Bioinformática VI)
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Informações sobre o curso
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Curso 6 de 7 no
Prazos flexíveis
Redefinir os prazos de acordo com sua programação.
Nível iniciante
Aprox. 21 horas para completar
Inglês
Legendas: Inglês
Programa - O que você aprenderá com este curso
4 horas para concluir
Week 1: Introduction to Read Mapping
<p>Welcome to our class! We are glad that you decided to join us.</p><p>In this class, we will consider the following two central biological questions (the computational approaches needed to solve them are shown in parentheses):</p><ol><li>How Do We Locate Disease-Causing Mutations? (<em>Combinatorial Pattern Matching</em>)</li><li>Why Have Biologists Still Not Developed an HIV Vaccine? (<em>Hidden Markov Models</em>)</li></ol><p>As in previous courses, each of these two chapters is accompanied by a Bioinformatics Cartoon created by talented artist Randall Christopher and serving as a chapter header in the Specialization's bestselling <a href="http://bioinformaticsalgorithms.com" target="_blank">print companion</a>. You can find the first chapter's cartoon at the bottom of this message. </p><p><img src="https://stepic.org/media/attachments/lessons/292/chapter7_cropped.jpg" title="Image: https://stepic.org/media/attachments/lessons/292/chapter7_cropped.jpg" width="528"></p>
4 horas para concluir
4 vídeos (Total 33 mín.), 2 leituras, 3 testes
4 videos
Why Do We Map Reads? 7min
Using the Trie 10min
From a Trie to a Suffix Tree 11min
2 leituras
Course Details10min
Week 1 FAQs (Optional)
1 exercício prático
How Do We Find Disease-Causing Mutations? (Week 1)15min
4 horas para concluir
Week 2: The Burrows-Wheeler Transform
<p>Welcome to week 2 of the class!</p>
4 horas para concluir
3 vídeos (Total 21 mín.), 1 leitura, 2 testes
3 videos
Inverting Burrows-Wheeler 13min
Using Burrows-Wheeler for Pattern Matching 2min
1 leituras
Week 2 FAQs (Optional)
4 horas para concluir
Week 3: Speeding Up Burrows-Wheeler Read Mapping
<p>Welcome to week 3 of class!</p>
4 horas para concluir
4 vídeos (Total 22 mín.), 1 leitura, 3 testes
4 videos
Setting Up Checkpoints 8min
Inexact Matching 6min
Further Applications of Read Mapping 2min
1 leituras
Week 3 FAQs (Optional)
1 exercício prático
How Do We Find Disease-Causing Mutations? (Weeks 2-3)20min
4 horas para concluir
Week 4: Introduction to Hidden Markov Models
<p>Welcome to week 4 of class!</p>
4 horas para concluir
5 vídeos (Total 42 mín.)
5 videos
Gambling with Yakuza 12min
From a Crooked Casino to a Hidden Markov Model 9min
The Decoding Problem 5min
The Viterbi Algorithm 7min
Avaliações
4.6
Principais avaliações do DECIFRANDO MUTAÇÕES NO DNA E NAS PROTEÍNAS (BIOINFORMÁTICA VI)
por TKJun 28, 2016
One of the best specialization on Coursera. Highly recommended for anyone who wants to apply his/her programming skills to fascinating real-world problems.
por DCSep 15, 2018
Really enjoyed this course. It was great to get to build on work from previous courses.
por ZXJul 20, 2019
In depth and comprehensive coverage of the topics in genetic data analysis.
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Universidade da Califórnia, San Diego
UC San Diego is an academic powerhouse and economic engine, recognized as one of the top 10 public universities by U.S. News and World Report. Innovation is central to who we are and what we do. Here, students learn that knowledge isn't just acquired in the classroom—life is their laboratory.
Sobre Programa de cursos integrados Bioinformática
Join Us in a Top 50 MOOC of All Time!
How do we sequence and compare genomes? How do we identify the genetic basis for disease? How do we construct an evolutionary Tree of Life for all species on Earth?
When you complete this Specialization, you will learn how to answer many questions in modern biology that have become inseparable from the computational approaches used to solve them. You will also obtain a toolkit of existing software resources built on these computational approaches and that are used by thousands of biologists every day in one of the fastest growing fields in science.
Although this Specialization centers on computational topics, you do not need to know how to program in order to complete it. If you are interested in programming, we feature an "Honors Track" (called "hacker track" in previous runs of the course). The Honors Track allows you to implement the bioinformatics algorithms that you will encounter along the way in dozens of automatically graded coding challenges. By completing the Honors Track, you will be a bioinformatics software professional!
Learn more about the Bioinformatics Specialization (including why we are wearing these crazy outfits) by watching our introductory video.
You can purchase the Specialization's print companion, Bioinformatics Algorithms: An Active Learning Approach, from the textbook website.
Our first course, "Finding Hidden Messages in DNA", was named a top-50 MOOC of all time by Class Central!
Perguntas Frequentes – FAQ
Quando terei acesso às palestras e às tarefas?
Ao se inscrever para um Certificado, você terá acesso a todos os vídeos, testes e tarefas de programação (se aplicável). Tarefas avaliadas pelos colegas apenas podem ser enviadas e avaliadas após o início da sessão. Caso escolha explorar o curso sem adquiri-lo, talvez você não consiga acessar certas tarefas.
O que recebo ao me inscrever nesta Especialização?
Quando você se inscreve no curso, tem acesso a todos os cursos na Especialização e pode obter um certificado quando concluir o trabalho. Seu Certificado eletrônico será adicionado à sua página de Participações e você poderá imprimi-lo ou adicioná-lo ao seu perfil no LinkedIn. Se quiser apenas ler e assistir o conteúdo do curso, você poderá frequentá-lo como ouvinte sem custo.
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