Informações sobre o curso
4.8
140 ratings
30 reviews
Learn how advances in biomedicine hold the potential to revolutionize drug development, drug treatments, and disease prevention: where are we now, and what does the future hold? This course will present short primers in genetics and mechanisms underlying variability in drug responses. A series of case studies will be used to illustrate principles of how genetics are being brought to bear on refining diagnoses and on personalizing treatment in rare and common diseases. The ethical and operational issues around how to implement large scale genomic sequencing in clinical practice will be addressed. After completing this course, learners will understand 1. The ways in which genetic variants can contribute to human disease susceptibility 2. How to choose among drug therapies based on genetic factors 3. That the functional consequences of the vast majority of genetic variants discovered by modern sequencing are unknown. This course is targeted primarily at physicians 5+ years out of training. Other healthcare providers, medical/health sciences students, and members of the public may also be interested. Course launches January 15, 2016. * The information presented in “Case Studies in Personalized Medicine” is offered for educational and informational purposes only, and should not be construed as personal medical advice. If you have questions or concerns about a medical matter, please consult your doctor or other professional healthcare provider....
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Sugerido: 2-4 hours/week

Aprox. 14 horas restantes
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English

Legendas: English
Globe

cursos 100% online

Comece imediatamente e aprenda em seu próprio cronograma.
Calendar

Prazos flexíveis

Redefinir os prazos de acordo com sua programação.
Clock

Sugerido: 2-4 hours/week

Aprox. 14 horas restantes
Comment Dots

English

Legendas: English

Programa - O que você aprenderá com este curso

1

Seção
Clock
3 horas para concluir

UNIT 1: INTRODUCTION TO PERSONALIZED MEDICINE

The first module of this course will focus on introducing the concept of personalized medicine. We will very briefly review fundamentals of genetics as these apply to personalized medicine (DNA structure; RNA; protein structures; function of DNA; coding; DNA variations; types of genetic variants), as well as review statistical concepts and skills important to clinical data analysis (odds ratios, relative risk, P values, multiple testing, sensitivity, specificity, ROCs). In Module 2 we will explore drug actions and reactions as we look closely at the general mechanisms underlying variability in drug responses, drug metabolism and transport, and genetic variability in drug-handling molecules....
Reading
11 vídeos (Total de 120 min), 1 leitura, 1 teste
Video11 videos
Introduction to Personalized Medicine11min
Genetics Definitions, Part I14min
Genetics Definitions, Part II & Types of Genetic Variants15min
Data Analysis, Part I: What is a Good Study?12min
Data Analysis, Part II: What is a Good Test?7min
Introduction to Drug Therapy and General Mechanisms Underlying Variability in Drug Responses13min
Variability in Drug Therapy15min
Drug Metabolism & Transport13min
Genetic Variability in Drug-Handling Molecules10min
**Inside VUMC: The Promise of Personalized Medicine1min
Reading1 leituras
About this course10min
Quiz1 exercício prático
Introduction to Personalized Medicine12min

2

Seção
Clock
2 horas para concluir

UNIT 2: STUDYING GENETIC VARIATION

Module 3 focuses on how we study genetic variation. We'll start by looking at families and populations. Topics that will be introduced include family history and inheritance patterns, ancestry, and linkage. Then in Module 4 we shift our focus to studying the contemporary techniques and technologies used to study genetic variation, including genome-wide association and sequencing....
Reading
7 vídeos (Total de 104 min), 1 teste
Video7 videos
Ancestry: Genetic Variation Across Generations and Geography17min
Finding Disease-Associated Genes: Linkage10min
**Inside VUMC: From Phenotype to Genotype and Back: Studying Heart Disease in Families1min
Genome-Wide Association25min
Sequencing28min
**Inside VUMC: History of Sequencing Technologies1min
Quiz1 exercício prático
Studying Genetic Variation12min

3

Seção
Clock
3 horas para concluir

UNIT 3: CASE STUDIES IN PERSONALIZED MEDICINE, PART 1

In Module 5 we will begin to discuss specific cases as these apply to personalized medicine. We will first look very closely at a case of familial hypercholesterolemia as we investigate how we use genomic medicine to move from a rare disease to a common medication, using genomics to find new drug targets, and a discussion of the side effects of statin therapy. In Module 6 we will look at a collection of "high risk pharmacogenetics"cases that illustrate adverse reactions due to drug metabolism and variable drug responses....
Reading
13 vídeos (Total de 174 min), 1 teste
Video13 videos
Using Genomics to Find New Drug Targets: Familial Hypercholesterolemia16min
Muscle Pains During Statin Therapy (Myopathy)13min
HLA-Mediated Immune Reactions (Skin Rash)9min
Long QT Syndromes, Part 115min
Long QT Syndromes, Part 218min
**Inside VUMC: Studying Cardiac Arrhythmias in Cells4min
A Second Heart Attack a Month After a First15min
Headache During Venlafaxine (Antidepressant)16min
Respiratory Arrest After Tonsillectomy10min
A Bleeding Complication 5 Days After Starting Warfarin21min
**Inside VUMC: Genotyping1min
Drug Metabolism and Variable Drug Responses – Four More Examples17min
Quiz1 exercício prático
Case Studies, Part I16min

4

Seção
Clock
2 horas para concluir

UNIT 4: CASE STUDIES IN PERSONALIZED MEDICINE, PART 2

Module 7 continues our focus on case studies with a look at some cases that illustrate how personalized medicine informs treatment decisions related to specific diseases/conditions. These include cystic fibrosis, Marfan syndrome, heart failure, neuropsychiatric diseases, and diabetes. Three cases/lessons focus specifically on how genomic medicine informs testing for and treatment of cancer. ...
Reading
9 vídeos (Total de 119 min), 1 teste
Video9 videos
Marfan Syndrome11min
A Case of Idiopathic Heart Failure16min
Personalizing Care in Neuropsychiatric Disease18min
Personalizing Care in Diabetes21min
Genomics to Subtype Cancer11min
A Family Member With Breast Cancer14min
A Family Member With Colon Cancer11min
**Inside VUMC: Organizing Infrastructure to Support Genetic Testing Decisions1min
Quiz1 exercício prático
Case Studies, Part II10min
4.8

Melhores avaliações

por MTApr 24th 2017

I learned more about pharmacogenomics and its application, which is crucial for my career development as a young graduate in biology who is pursuing health sciences.

por CZNov 13th 2016

Thank you! I think I'm going to review/re-take this course at least one more time as the lectures are really interesting and insightful.

Instrutores

Dan Roden, M.D.

Professor of Medicine and Pharmacology
Assistant Vice Chancellor for Personalized Medicine

Sobre Vanderbilt University

Vanderbilt University, located in Nashville, Tenn., is a private research university and medical center offering a full-range of undergraduate, graduate and professional degrees....

Perguntas Frequentes – FAQ

  • Once you enroll for a Certificate, you’ll have access to all videos, quizzes, and programming assignments (if applicable). Peer review assignments can only be submitted and reviewed once your session has begun. If you choose to explore the course without purchasing, you may not be able to access certain assignments.

  • When you purchase a Certificate you get access to all course materials, including graded assignments. Upon completing the course, your electronic Certificate will be added to your Accomplishments page - from there, you can print your Certificate or add it to your LinkedIn profile. If you only want to read and view the course content, you can audit the course for free.

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