Informações sobre o curso
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Are you a living creature? Then, congratulations! You’ve got DNA. But how much do you really know about the microscopic molecules that make you unique? Why is DNA called the “blueprint of life”? What is a “DNA fingerprint”? How do scientists clone DNA? What can DNA teach you about your family history? Are Genetically Modified Organisms (GMOs) safe? Is it possible to revive dinosaurs by cloning their DNA? DNA Decoded answers these questions and more. If you’re curious about DNA, join Felicia Vulcu and Caitlin Mullarkey, two biochemists from McMaster University, as they explore the structure of DNA, how scientists cracked the genetic code, and what our DNA can tell us about ourselves. Along the way, you’ll learn about the practical techniques that scientists use to analyze our genetic risks, to manipulate DNA, and to develop new treatments for a range of different diseases. Then, step into our virtual lab to perform your own forensic DNA analysis of samples from a crime scene and solve a murder....
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Intermediate Level

Nível intermediário

Clock

Sugerido: 6 hours/week

Aprox. 8 horas restantes
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English

Legendas: English
Globe

cursos 100% online

Comece imediatamente e aprenda em seu próprio cronograma.
Calendar

Prazos flexíveis

Redefinir os prazos de acordo com sua programação.
Intermediate Level

Nível intermediário

Clock

Sugerido: 6 hours/week

Aprox. 8 horas restantes
Comment Dots

English

Legendas: English

Programa - O que você aprenderá com este curso

1

Seção
Clock
3 horas para concluir

Cracking the Genetic Code

In this module, we'll explore the molecular structure of DNA. What is DNA? What are the basic building blocks of DNA? Where can you find DNA within a cell? We'll learn about how James Watson and Francis Crick were able to solve the riddle of the molecular structure of DNA by building on the work of other scientists. Their groundbreaking discovery revealed that four nucleobases (adenine, thymine, cytosine, and guanine) combine with sugar and phosphate molecules to form the familiar double helix of DNA. We'll take a look at how the molecular structure of DNA regulates its functions; for example, how the chemical bonds (covalent and noncovalent) between these molecules allow DNA to "unzip" during replication. Then we'll take a look at how you manage to fit over three billion base pairs into each of your cells. (Here's a hint: Histones, nucleosomes, and chromosomes would be great at packing for a trip!)...
Reading
7 vídeos (Total de 45 min), 4 leituras, 6 testes
Video7 videos
How to Speak DNA4min
Cracking the Genetic Code4min
The Building Blocks of DNA5min
Packing it all in!6min
Summing Up1min
The Double Helix16min
Reading4 leituras
Timeline of DNA Discoveries10min
Behind the Picture: Photo 51 (interview)10min
(Not Really) The Last Word about DNA (video)10min
Biochemistry: The Operating System of Life (video)10min
Quiz6 exercícios práticos
How to Speak DNA6min
Cracking the Genetic Code6min
The Building Blocks of DNA8min
Packing it all in!6min
DNA Word Search2min
Cracking the Genetic Code22min

2

Seção
Clock
3 horas para concluir

Getting the Message Across: Transcription, Translation, and Replication

We've all heard DNA described as "the blueprint of life," but what does that actually mean? Each one of the approximately 20,000 genes in our bodies contains the instructions for building a protein. In this module, we'll explain how RNA copies the genetic information contained in our genes and uses this information to assemble amino acids into proteins. Scientists call this concept "Central Dogma": DNA makes RNA and RNA makes protein. We'll also explore how we transmit genetic information from one cell to another -- and what happens when things go wrong. Along the way, we'll learn about techniques (such as polymerase chain reactions and gel electrophoresis) that forensic scientists use in DNA fingerprinting. Join us this week for murder and mayhem in the lab!...
Reading
8 vídeos (Total de 52 min), 4 leituras, 9 testes
Video8 videos
Stop copying me! DNA Replication6min
Central Dogma, Part I: Transcription8min
Central Dogma, Part II: Translation7min
Practical DNA: Polymerase Chain Reaction (PCR)8min
Practical DNA: Gel Electrophoresis7min
Summing Up3min
DNA Replication3min
Reading4 leituras
The Case of the Silenced Scientist10min
Labster: Crime Scene Investigation10min
TED Talk: Drew Barry - Animations of Unseeable Biology (video)10min
Protein Data Bank10min
Quiz9 exercícios práticos
The Scene of the Crime4min
Stop copying me! DNA Replication4min
Central Dogma, Pt 1: Transcription8min
Central Dogma, Pt 2: Translation6min
Decipher the Secret Message2min
Breaking the Code (aka Game of Codons)4min
Polymerase Chain Reaction (PCR)4min
Gel Electrophoresis6min
Getting the Message Across16min

3

Seção
Clock
3 horas para concluir

Manipulating DNA

In this module, we'll explore the techniques scientists use to manipulate DNA. Genetic engineering has allowed us to increase crop yields, diagnose illnesses, develop vaccines, and manufacture insulin. By carefully selecting a pair of molecular scissors (restriction enzymes), scientists are able to isolate a gene of interest and insert it into plasmid DNA, turning a common bacteria (E. coli) into a molecular copying machine. This week, we'll learn that mutations are genetic errors, but that not all mutations are necessarily bad — in fact, some mutations confer a selective advantage that protects against disease. We'll explain what genetically modified organisms are (and what they are not) and weigh in on the heated debates about the ethics and safety of GMOs in popular media....
Reading
8 vídeos (Total de 46 min), 5 leituras, 7 testes
Video8 videos
Slice and Dice: Restriction Enzymes10min
Lights, Camera, Transformations6min
Mutations, Mutations, Mutations!6min
From Bananas to Papayas: Genetically Modified Organisms (GMOs)9min
Summing Up4min
Genetic Engineering1min
Sickle Cell Anemiamin
Reading5 leituras
Labster: Molecular Cloning Simulation10min
Creating Dolly (video)10min
Genetic Engineering and Working with DNA (video)10min
How did they make insulin from recombinant DNA? (article)10min
Massive Review Reveals Consensus on GMO Safety (article)10min
Quiz7 exercícios práticos
Freaky Fruit: Manipulating DNA6min
Slice and Dice: Restriction Enzymes6min
Lights, Camera, Transformations6min
Mutations, mutations, mutations6min
From Papayas to Bananas: Genetically Modified Organisms (GMOs)6min
Help Felicia design a blue tomato!8min
Manipulating DNA16min

4

Seção
Clock
3 horas para concluir

DNA and Me

What does your DNA say about you? You may have heard that you share 99% of your genetic material with everyone else on the planet. That's true, but this week we're going to take a look at the less than 1% that makes you unique. We'll kick off by discussing the Human Genome Project, the massive scientific collaboration that mapped out the sequence of all our genetic material. The technologies developed while mapping out the human genome ushered in a new age in DNA research. Now, genome-wide association studies can analyze massive amounts of data, searching for genetic variations that are associated with particular diseases. Pharmacogenomics may help determine which drugs are likely be most effective for you. Genetic genealogy tests (such as Ancestry DNA, 23 and Me, and Family Tree DNA) will allow you to trace random mutations in your DNA that can provide clues to your ethnic heritage. As an added bonus, we'll discuss whether it would be possible to revive extinct species by studying ancient DNA....
Reading
9 vídeos (Total de 45 min), 7 leituras, 6 testes
Video9 videos
Sanger Sequencing3min
The Human Genome Project5min
Mammoths, Mummies, and Microbes: Ancient DNA10min
Me and My Family Tree8min
DNA and My Health5min
That's a wrap!5min
Sanger Sequencingmin
Human Genome Sequencing1min
Reading7 leituras
Labster: Next Generation Sequencing Simulation10min
Cracking the Code of Life (video)10min
Iceman Murder Mystery (video)10min
Personal DNA Testing (video)10min
My Career in Genomics: Antibiotic Resistance (video)10min
My Career in Genomics: Cancer Biology (video)10min
My Career in Genomics: Evolution (video)10min
Quiz6 exercícios práticos
DNA: Our Genetic Blueprint2min
Sanger Sequencing8min
Me and My Family Tree4min
DNA and My Health2min
DNA and Me18min
Scientists Complete First Chapter of Book of Life With Decoding of First Human Chromosome (article)4min

Instrutores

Caitlin Mullarkey

Assistant Professor
Health Sciences

Felicia Vulcu

Assistant Professor
Biochemistry and Biomedical Sciences

Sobre McMaster University

Founded in 1887, McMaster University is committed to creativity, innovation, and excellence by inspiring critical thinking, personal growth, and a passion for learning. Ranked amongst the Top 100 universities in the world, McMaster pioneered a learner-centred, problem-based, interdisciplinary approach to learning that is now known worldwide as the “McMaster Model”. ...

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