Informações sobre o curso
4.8
391 classificações
100 avaliações
100% online

100% online

Comece imediatamente e aprenda em seu próprio cronograma.
Prazos flexíveis

Prazos flexíveis

Redefinir os prazos de acordo com sua programação.
Horas para completar

Aprox. 30 horas para completar

Sugerido: 7 weeks of study, 6-8 hours/week...
Idiomas disponíveis

Inglês

Legendas: Inglês

Habilidades que você terá

CancerMolecular BiologyCancer EpigeneticsDna Methylation
100% online

100% online

Comece imediatamente e aprenda em seu próprio cronograma.
Prazos flexíveis

Prazos flexíveis

Redefinir os prazos de acordo com sua programação.
Horas para completar

Aprox. 30 horas para completar

Sugerido: 7 weeks of study, 6-8 hours/week...
Idiomas disponíveis

Inglês

Legendas: Inglês

Programa - O que você aprenderá com este curso

Semana
1
Horas para completar
2 horas para concluir

Week 1 - Introduction to Epigenetic Control

An introduction to and definition of epigenetic control of gene expression, and its importance in normal development. We will learn what chromatin is, and how its composition and packaging can alter gene expression. We’ll also discuss the best-characterised epigenetic modification, DNA methylation, and how it is not only implicated in regulating gene expression, but also in maintaining genome stability. ...
Reading
7 vídeos (total de (Total 65 mín.) min), 5 leituras, 1 teste
Video7 videos
1.1 Introduction to the concepts of epigenetic control10min
1.2 Mitotic heritability of epigenetic marks10min
1.3 Chromatin and the nucleosome6min
1.4 Chromatin compaction - heterochromatin versus euchromatin9min
1.5 DNA methylation at CpG islands11min
1.6 DNA methylation at intergenic regions and repetitive elements15min
Reading5 leituras
Course syllabus10min
Teaching team10min
Start of course survey10min
Assessment and grading policy10min
Week 1 and 2 resources10min
Quiz1 exercício prático
Week 1 quiz - contributes 8% towards your final grade20min
Semana
2
Horas para completar
2 horas para concluir

Week 2 - Epigenetic Modifications and Organisation of the Nucleus

We’ll discuss the molecular mechanisms for regulating gene expression in some detail, from how the DNA is packaged at a local level, right up to how the chromatin is positioned within the nucleus. We’ll learn about the chromatin modifications implicated in gene silencing and activation, the role of non-coding RNA, and higher order chromatin structures. This week will provide you with a good understanding of the basic mechanisms that will help you understand the processes we discuss throughout the rest of the course. ...
Reading
9 vídeos (total de (Total 90 mín.) min), 1 leitura, 1 teste
Video9 videos
2.2 Histone acetylation and histone methylation12min
2.3 Chromatin remodelling12min
2.4 Histone variants8min
2.5 Noncoding RNAs - microRNAs6min
2.6 Noncoding RNAs - piRNAs9min
2.7 Noncoding RNAs - long noncoding RNAs introduction10min
2.8 Long noncoding RNAs Xist and HOTAIR7min
2.9 3D organisation of the nucleus and summary of epigenetic marks17min
Reading1 leituras
Week 1 and 2 resources10min
Quiz1 exercício prático
Week 2 quiz - contributes 8% towards your final grade20min
Semana
3
Horas para completar
3 horas para concluir

Week 3 - Dosage Compensation

X chromosome inactivation is a really well-characterised epigenetic process that is now used as a model system to study epigenetic processes that are relevant more broadly. This is because it uses many epigenetic mechanisms, at many levels, to achieve really stable silencing of a whole chromosome. We’ll learn about this process and how it occurs in a mouse in great detail, which will greatly add to the mechanistic understanding gained in week two. We will then briefly discuss alternate mechanisms for dosage compensation that occur in other organisms. ...
Reading
12 vídeos (total de (Total 113 mín.) min), 1 leitura, 1 teste
Video12 videos
3.2 Timing of random and imprinted X chromosome inactivation8min
3.3 Stages of X inactivation - counting and control of Xist expression13min
3.4 Control of Xist expression by pluripotency factors6min
3.5 Stages of X inactivation - choice of which X to inactivate9min
3.6 Stages of X inactivation - initiation and spreading of silencing11min
3.7 Stages of X inactivation - establishment of silencing6min
3.8 Stages of X inactivation - maintenance of silencing e.g. Dnmt18min
3.9 Stages of X inactivation - maintenance of silencing e.g. Smchd18min
3.10 X chromosome inactivation summary10min
3.11 Dosage compensation in flies and worms, compared with mammals8min
3.12 Lessons from the fly - position effect variegation and screening for epigenetic modifiers10min
Reading1 leituras
Week 3 resources (including required readings)10min
Quiz1 exercício prático
Week 3 quiz - contributes 12% towards your final grade30min
Semana
4
Horas para completar
2 horas para concluir

Week 4 - Genomic Imprinting and Epigenetic Reprogramming

We’ll learn about the two important periods during development for the erasure and resetting of the epigenome. There are two well-characterised features that are treated differently during epigenetic reprogramming; imprinted genes and repeats. We’ll learn about mechanisms for genomic imprinting, and study three examples in more depth....
Reading
6 vídeos (total de (Total 68 mín.) min), 1 leitura, 1 teste
Video6 videos
4.2 Epigenetic reprogramming of imprinted genes and repetitive elements11min
4.3 Location of imprinted genes in the genome and bisulfite sequencing10min
4.4 Kcnq1 and H19/Igf2 ICR mechanisms of action and Beckwith Weidemann syndrome17min
4.5 Snrpn ICR mechanism, Prader Willi and Angelman syndromes13min
4.6 Summary of epigenetic reprogramming and imprinting6min
Reading1 leituras
Week 4 resources (including required reading)10min
Quiz1 exercício prático
Week 4 quiz - contributes 12% towards your final grade30min
4.8
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Direcionamento de carreira

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Benefício de carreira

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Promoção de carreira

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Melhores avaliações

por MMOct 2nd 2018

This was an excellent course. All the material was well presented and the explanation of the sometimes complex subject matter was clear and understandable. Thank you for an great learning experience.

por DSAug 25th 2018

This is an excellent course that introduces you to fundamental knowledge of several hot topics in the field of epigenetics. Dr. Blewitt herself studies X inactivation, and I learned so much!

Instrutores

Avatar

Dr. Marnie Blewitt

Head, Molecular Medicine Laboratory
Walter and Eliza Hall Institute of Medical Research

Sobre Universidade de Melbourne

The University of Melbourne is an internationally recognised research intensive University with a strong tradition of excellence in teaching, research, and community engagement. Established in 1853, it is Australia's second oldest University....

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