While the human genome sequence has transformed our understanding of human biology, it isn’t just the sequence of your DNA that matters, but also how you use it! How are some genes activated and others are silenced? How is this controlled? The answer is epigenetics.
oferecido por
Controle Epigenético da Expressão Gênica
Universidade de Melbourne
Informações sobre o curso
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Habilidades que você terá
CancerMolecular BiologyCancer EpigeneticsDna Methylation
Resultados de carreira do aprendiz
33%
comecei uma nova carreira após concluir estes cursos
38%
consegui um benefício significativo de carreira com este curso
11%
recebi um aumento ou promoção
100% on-line
Comece imediatamente e aprenda em seu próprio cronograma.
Prazos flexíveis
Redefinir os prazos de acordo com sua programação.
Aprox. 30 horas para completar
Sugerido: 7 weeks of study, 6-8 hours/week
Inglês
Legendas: Inglês, Espanhol
Programa - O que você aprenderá com este curso
2 horas para concluir
Week 1 - Introduction to Epigenetic Control
An introduction to and definition of epigenetic control of gene expression, and its importance in normal development. We will learn what chromatin is, and how its composition and packaging can alter gene expression. We’ll also discuss the best-characterised epigenetic modification, DNA methylation, and how it is not only implicated in regulating gene expression, but also in maintaining genome stability.
2 horas para concluir
7 vídeos (Total 65 mín.), 5 leituras, 1 teste
7 videos
Course overview1min
1.1 Introduction to the concepts of epigenetic control10min
1.2 Mitotic heritability of epigenetic marks10min
1.3 Chromatin and the nucleosome6min
1.4 Chromatin compaction - heterochromatin versus euchromatin9min
1.5 DNA methylation at CpG islands11min
1.6 DNA methylation at intergenic regions and repetitive elements15min
5 leituras
Course syllabus10min
Teaching team10min
Start of course survey10min
Assessment and grading policy10min
Week 1 and 2 resources10min
1 exercício prático
Week 1 quiz - contributes 8% towards your final grade20min
2 horas para concluir
Week 2 - Epigenetic Modifications and Organisation of the Nucleus
We’ll discuss the molecular mechanisms for regulating gene expression in some detail, from how the DNA is packaged at a local level, right up to how the chromatin is positioned within the nucleus. We’ll learn about the chromatin modifications implicated in gene silencing and activation, the role of non-coding RNA, and higher order chromatin structures. This week will provide you with a good understanding of the basic mechanisms that will help you understand the processes we discuss throughout the rest of the course.
2 horas para concluir
9 vídeos (Total 90 mín.), 1 leitura, 1 teste
9 videos
2.2 Histone acetylation and histone methylation12min
2.3 Chromatin remodelling12min
2.4 Histone variants8min
2.5 Noncoding RNAs - microRNAs6min
2.6 Noncoding RNAs - piRNAs9min
2.7 Noncoding RNAs - long noncoding RNAs introduction10min
2.8 Long noncoding RNAs Xist and HOTAIR7min
2.9 3D organisation of the nucleus and summary of epigenetic marks17min
1 leituras
Week 1 and 2 resources10min
1 exercício prático
Week 2 quiz - contributes 8% towards your final grade20min
3 horas para concluir
Week 3 - Dosage Compensation
X chromosome inactivation is a really well-characterised epigenetic process that is now used as a model system to study epigenetic processes that are relevant more broadly. This is because it uses many epigenetic mechanisms, at many levels, to achieve really stable silencing of a whole chromosome. We’ll learn about this process and how it occurs in a mouse in great detail, which will greatly add to the mechanistic understanding gained in week two. We will then briefly discuss alternate mechanisms for dosage compensation that occur in other organisms.
3 horas para concluir
12 vídeos (Total 113 mín.), 1 leitura, 1 teste
12 videos
3.2 Timing of random and imprinted X chromosome inactivation8min
3.3 Stages of X inactivation - counting and control of Xist expression13min
3.4 Control of Xist expression by pluripotency factors6min
3.5 Stages of X inactivation - choice of which X to inactivate9min
3.6 Stages of X inactivation - initiation and spreading of silencing11min
3.7 Stages of X inactivation - establishment of silencing6min
3.8 Stages of X inactivation - maintenance of silencing e.g. Dnmt18min
3.9 Stages of X inactivation - maintenance of silencing e.g. Smchd18min
3.10 X chromosome inactivation summary10min
3.11 Dosage compensation in flies and worms, compared with mammals8min
3.12 Lessons from the fly - position effect variegation and screening for epigenetic modifiers10min
1 leituras
Week 3 resources (including required readings)10min
1 exercício prático
Week 3 quiz - contributes 12% towards your final grade30min
2 horas para concluir
Week 4 - Genomic Imprinting and Epigenetic Reprogramming
We’ll learn about the two important periods during development for the erasure and resetting of the epigenome. There are two well-characterised features that are treated differently during epigenetic reprogramming; imprinted genes and repeats. We’ll learn about mechanisms for genomic imprinting, and study three examples in more depth.
2 horas para concluir
6 vídeos (Total 68 mín.), 1 leitura, 1 teste
6 videos
4.2 Epigenetic reprogramming of imprinted genes and repetitive elements11min
4.3 Location of imprinted genes in the genome and bisulfite sequencing10min
4.4 Kcnq1 and H19/Igf2 ICR mechanisms of action and Beckwith Weidemann syndrome17min
4.5 Snrpn ICR mechanism, Prader Willi and Angelman syndromes13min
4.6 Summary of epigenetic reprogramming and imprinting6min
1 leituras
Week 4 resources (including required reading)10min
1 exercício prático
Week 4 quiz - contributes 12% towards your final grade30min
Avaliações
Principais avaliações do CONTROLE EPIGENÉTICO DA EXPRESSÃO GÊNICA
por MMOct 1, 2018
This was an excellent course. All the material was well presented and the explanation of the sometimes complex subject matter was clear and understandable. Thank you for an great learning experience.
por DSAug 24, 2018
This is an excellent course that introduces you to fundamental knowledge of several hot topics in the field of epigenetics. Dr. Blewitt herself studies X inactivation, and I learned so much!
por HDNov 24, 2019
Update the reading for the final assignment. It is too old and updating it would be an easy fix. I am not going to finish the certificate as the final paper is 7 years ago. Go Boomer. Sad
por BMAug 13, 2017
One of the best organized and implemented courses I have taken so far. For someone who had barely any experience with epigenetics, I feel this gave me a proper introduction to the field.
por HHDec 17, 2016
A quintessential course for Genetics students all over the world. Very nicely prepared and elucidated by Dr. Marnie Blewitt .\n\nMany many thanks to Dr. Marnie Blewitt & Coursera team.
por TWAug 23, 2017
Very informative! Before starting this course I didn't even know epigenetics was a word. Now I feel I have a very good grasp of the basics of one of the core concepts of genetics.
por DBSep 27, 2016
This was an AWESOME course. Really exciting, interesting, AND surprising, I never thought there's that much to talk about in epigenetics! I'm going to recommend it, definitely :)
por VSAug 7, 2018
A very informative course which starts from the basics and goes up all the way and the pace of the course is also perfectly set for anyone from professionals to first-timers.
por ZLDec 11, 2016
Well constructed course and carefully designed questions. It is very useful for someone with biological and/or biomedical background to expand their knowledge on epigenetics!
por LMJun 18, 2016
The course is very interesting for those who like Genetics. The lectures are delivered in an understandable manner, and the motion pictures make everything clear right away.
por AANov 26, 2019
The lectures were enlightening and easy to follow and understand. there were also a lot of examples that made the lectures easy to understand. I totally loved and enjoyed it
por ASJul 20, 2019
A great learning platform. This was my first ever course on coursera and I've thoroughly enjoyed it. A big thank you to Dr. Marnie Blewitt for helping us learn in a fun way!
por ALDec 10, 2016
Excellent course by an expert in the field. Full appreciation requires a background in biochemistry and genetics, but still a lot can be learned by anyone with interest.
por HKNov 16, 2018
This course is well taught and some important concepts are repeated over and over again during the course so the concept lingers in the brain as if it was there already.
por AMDec 12, 2016
A great course! I certainly learnt a lot. Please note, that if you haven't studied a scientific course before, then I think you would find this course too challenging.
por MKMay 10, 2016
Absolutely amazing experience! Every week was very captivating . Focus is on concepts and assignments test the understanding of them. Thank you Dr. Blewitt!!
por BHMay 1, 2017
The course was great! I did not know much about epigenetics beforehand and now I feel like I could have an informed conversation. My curiosity was awakend
por MNFeb 22, 2020
A great course for students of biotechnology and bioinformatics. I wish i could study in such university by the great respectable teachers.
por KSDec 23, 2017
This is an awesome course which provides intriguing yet interesting insights in epigenetics and gene regulation as well as expression!!
por TGAug 6, 2017
One of the best course on Coursera on this topic for experts and not so. Thanks a lot and I'll be glad to see follow up on the subject.
oferecido por
Universidade de Melbourne
The University of Melbourne is an internationally recognised research intensive University with a strong tradition of excellence in teaching, research, and community engagement. Established in 1853, it is Australia's second oldest University.
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