While the human genome sequence has transformed our understanding of human biology, it isn’t just the sequence of your DNA that matters, but also how you use it! How are some genes activated and others are silenced? How is this controlled? The answer is epigenetics.
Controle Epigenético da Expressão Gênica
Universidade de MelbourneInformações sobre o curso
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Resultados de carreira do aprendiz
27%
comecei uma nova carreira após concluir estes cursos
30%
consegui um benefício significativo de carreira com este curso
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Prazos flexíveis
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Aprox. 17 horas para completar
Inglês
Legendas: Árabe, Francês, Português (Brasil), Italiano, Vietnamita, Coreano, Alemão, Russo, Turco, Inglês, Espanhol, Chinês
Habilidades que você terá
CancerMolecular BiologyCancer EpigeneticsDna Methylation
Resultados de carreira do aprendiz
27%
comecei uma nova carreira após concluir estes cursos
30%
consegui um benefício significativo de carreira com este curso
Certificados compartilháveis
Tenha o certificado após a conclusão
100% on-line
Comece imediatamente e aprenda em seu próprio cronograma.
Prazos flexíveis
Redefinir os prazos de acordo com sua programação.
Aprox. 17 horas para completar
Inglês
Legendas: Árabe, Francês, Português (Brasil), Italiano, Vietnamita, Coreano, Alemão, Russo, Turco, Inglês, Espanhol, Chinês
oferecido por
Universidade de Melbourne
The University of Melbourne is an internationally recognised research intensive University with a strong tradition of excellence in teaching, research, and community engagement. Established in 1853, it is Australia's second oldest University.
Programa - O que você aprenderá com este curso
2 horas para concluir
Week 1 - Introduction to Epigenetic Control
An introduction to and definition of epigenetic control of gene expression, and its importance in normal development. We will learn what chromatin is, and how its composition and packaging can alter gene expression. We’ll also discuss the best-characterised epigenetic modification, DNA methylation, and how it is not only implicated in regulating gene expression, but also in maintaining genome stability.
2 horas para concluir
7 vídeos (Total 65 mín.), 5 leituras, 1 teste
7 videos
Course overview1min
1.1 Introduction to the concepts of epigenetic control10min
1.2 Mitotic heritability of epigenetic marks10min
1.3 Chromatin and the nucleosome6min
1.4 Chromatin compaction - heterochromatin versus euchromatin9min
1.5 DNA methylation at CpG islands11min
1.6 DNA methylation at intergenic regions and repetitive elements15min
5 leituras
Course syllabus10min
Teaching team10min
Start of course survey10min
Assessment and grading policy10min
Week 1 and 2 resources10min
1 exercício prático
Week 1 quiz - contributes 8% towards your final grade30min
2 horas para concluir
Week 2 - Epigenetic Modifications and Organisation of the Nucleus
We’ll discuss the molecular mechanisms for regulating gene expression in some detail, from how the DNA is packaged at a local level, right up to how the chromatin is positioned within the nucleus. We’ll learn about the chromatin modifications implicated in gene silencing and activation, the role of non-coding RNA, and higher order chromatin structures. This week will provide you with a good understanding of the basic mechanisms that will help you understand the processes we discuss throughout the rest of the course.
2 horas para concluir
9 vídeos (Total 90 mín.), 1 leitura, 1 teste
9 videos
2.2 Histone acetylation and histone methylation12min
2.3 Chromatin remodelling12min
2.4 Histone variants8min
2.5 Noncoding RNAs - microRNAs6min
2.6 Noncoding RNAs - piRNAs9min
2.7 Noncoding RNAs - long noncoding RNAs introduction10min
2.8 Long noncoding RNAs Xist and HOTAIR7min
2.9 3D organisation of the nucleus and summary of epigenetic marks17min
1 leituras
Week 1 and 2 resources10min
1 exercício prático
Week 2 quiz - contributes 8% towards your final grade30min
3 horas para concluir
Week 3 - Dosage Compensation
X chromosome inactivation is a really well-characterised epigenetic process that is now used as a model system to study epigenetic processes that are relevant more broadly. This is because it uses many epigenetic mechanisms, at many levels, to achieve really stable silencing of a whole chromosome. We’ll learn about this process and how it occurs in a mouse in great detail, which will greatly add to the mechanistic understanding gained in week two. We will then briefly discuss alternate mechanisms for dosage compensation that occur in other organisms.
3 horas para concluir
12 vídeos (Total 113 mín.), 1 leitura, 1 teste
12 videos
3.2 Timing of random and imprinted X chromosome inactivation8min
3.3 Stages of X inactivation - counting and control of Xist expression13min
3.4 Control of Xist expression by pluripotency factors6min
3.5 Stages of X inactivation - choice of which X to inactivate9min
3.6 Stages of X inactivation - initiation and spreading of silencing11min
3.7 Stages of X inactivation - establishment of silencing6min
3.8 Stages of X inactivation - maintenance of silencing e.g. Dnmt18min
3.9 Stages of X inactivation - maintenance of silencing e.g. Smchd18min
3.10 X chromosome inactivation summary10min
3.11 Dosage compensation in flies and worms, compared with mammals8min
3.12 Lessons from the fly - position effect variegation and screening for epigenetic modifiers10min
1 leituras
Week 3 resources (including required readings)10min
1 exercício prático
Week 3 quiz - contributes 12% towards your final grade30min
2 horas para concluir
Week 4 - Genomic Imprinting and Epigenetic Reprogramming
We’ll learn about the two important periods during development for the erasure and resetting of the epigenome. There are two well-characterised features that are treated differently during epigenetic reprogramming; imprinted genes and repeats. We’ll learn about mechanisms for genomic imprinting, and study three examples in more depth.
2 horas para concluir
6 vídeos (Total 68 mín.), 1 leitura, 1 teste
6 videos
4.2 Epigenetic reprogramming of imprinted genes and repetitive elements11min
4.3 Location of imprinted genes in the genome and bisulfite sequencing10min
4.4 Kcnq1 and H19/Igf2 ICR mechanisms of action and Beckwith Weidemann syndrome17min
4.5 Snrpn ICR mechanism, Prader Willi and Angelman syndromes13min
4.6 Summary of epigenetic reprogramming and imprinting6min
1 leituras
Week 4 resources (including required reading)10min
1 exercício prático
Week 4 quiz - contributes 12% towards your final grade30min
Avaliações
Principais avaliações do CONTROLE EPIGENÉTICO DA EXPRESSÃO GÊNICA
por MM1 de Out de 2018
This was an excellent course. All the material was well presented and the explanation of the sometimes complex subject matter was clear and understandable. Thank you for an great learning experience.
por GK19 de Mai de 2020
This course was new to me. All the concepts were explained in a very simplified manner. I am very happy to have done this course and find it a very interesting field to take upm in my future career.
por CY9 de Mai de 2020
Very clear explanation of the concepts and details. I would say it is a difficult course for students from engineering background, even having some bioinfomatics and oncology courses background
por DS24 de Ago de 2018
This is an excellent course that introduces you to fundamental knowledge of several hot topics in the field of epigenetics. Dr. Blewitt herself studies X inactivation, and I learned so much!
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