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100% online

Comece imediatamente e aprenda em seu próprio cronograma.

Prazos flexíveis

Redefinir os prazos de acordo com sua programação.

Aprox. 18 horas para completar

Sugerido: 14.5 hours of videos...

Inglês

Legendas: Inglês

Programa - O que você aprenderá com este curso

Semana
1
1 hora para concluir

Welcome

Welcome to the course!...
3 vídeos (total de (Total 19 mín.) min), 3 leituras
3 videos
Description of Parts7min
Introduction: Why Electrons?8min
3 leituras
Welcome from Professor Jensen10min
About the Instructor10min
Concept Check Questions: Why Electrons?10min
Semana
2
3 horas para concluir

Currents, Coils, Knobs and Names: Basic anatomy of the electron microscope

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9 vídeos (total de (Total 94 mín.) min), 8 leituras
9 videos
Electron Guns18min
EM Lenses
The Column26min
Sample Chamber14min
Energy Filters7min
Detectors11min
Vacuum Systems9min
Summary and Safety5min
8 leituras
Concept Check Questions: Electron Guns10min
Concept Check Questions: Electron Lenses10min
Concept Check Questions: The Column10min
Concept Check Questions: The Sample Chamber10min
Concept Check Questions: Energy Filters10min
Concept Check Questions: Electron Detectors10min
Concept Check Questions: Vacuum Systems10min
Concept Check Questions: Summary and Safety10min
Semana
3
3 horas para concluir

Fourier Transforms and Reciprocal Space for Beginners

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7 vídeos (total de (Total 134 mín.) min), 6 leituras
7 videos
1-D Sine Waves and their Sums32min
1-D Reciprocal Space20min
2-D Waves and Images19min
2-D Transforms and Filters32min
3-D Waves and Transforms13min
Convolution and Cross-Correlation15min
6 leituras
Concept Check Questions: 1-D Sine Waves and Their Sums10min
Concept Check Questions: 1-D Reciprocal Space10min
Concept Check Questions: 2-D Waves and Images10min
Concept Check Questions: 2-D Transforms and Filters10min
Concept Check Questions: 3-D Waves and Transforms10min
Concept Check Questions: Convolution and Cross-correlation10min
Semana
4
4 horas para concluir

Image Formation

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7 vídeos (total de (Total 164 mín.) min), 6 leituras
7 videos
Amplitude and Phase Contrast30min
Wave Propagation and Phase Shifts30min
The Contrast Transfer Function33min
Defocus and its Effects21min
Envelopes16min
CTF Correction31min
6 leituras
Concept Check Questions: Amplitude and Phase Contrast10min
Concept Check Questions: Wave Propagation and Phase Shifts10min
Concept Check Questions: The Contrast Transfer Function10min
Concept Check Questions: Defocus and its Effects10min
Concept Check Questions: Envelopes10min
Concept Check Questions: CTF Correction10min
Semana
5
2 horas para concluir

Fundamental Challenges in Biological EM

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6 vídeos (total de (Total 96 mín.) min), 5 leituras
6 videos
Sample Prep - Room Temperature Methods20min
Sample Prep Methods Involving Freezing27min
Sample Prep Grids11min
3-D Reconstruction11min
Dose Limitations22min
5 leituras
Concept Check Questions: Sample Prep - Room Temperature Methods10min
Concept Check Questions: Sample Prep - Methods Involving Freezing10min
Concept Check Questions: Sample Prep - Grids10min
Concept Check Questions: 3-D Reconstruction10min
Concept Check Questions: Dose Limitations10min
Semana
6
4 horas para concluir

Single Particle Analysis

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5 vídeos (total de (Total 159 mín.) min), 6 leituras
5 videos
Data collection (imaging)21min
Reconstruction basics31min
Reconstruction: additional topics44min
Interpretation and limitations38min
6 leituras
Concept check questions: Introduction to single particle analysis10min
Concept Check Questions: Special sample prep issues10min
Concept Check Questions: Data collection (imaging)10min
Concept Check Questions: Reconstruction basics10min
Concept Check Questions: Reconstruction - additional topics10min
Concept Check Questions: Interpretation and limitations10min
Semana
7
3 horas para concluir

Tomography

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5 vídeos (total de (Total 131 mín.) min), 5 leituras
5 videos
Tomography Data Collection and Reconstruction40min
Tomography Identifying Objects of Interest24min
Tomography Limitations29min
Tomography Parameters and Handedness12min
5 leituras
Concept Check Questions: Introduction: Tomography10min
Concept Check Questions: Tomography Data Collection and Reconstruction10min
Concept Check Questions: Identifying Objects in Tomograms10min
Concept Check Questions: Tomography Limitations10min
Concept Check Questions: Tomography Parameters and Handedness10min
Semana
8
2 horas para concluir

2-D Crystallography

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5 vídeos (total de (Total 55 mín.) min), 4 leituras
5 videos
FT of a 2-D Crystal24min
2-D Crystallography Data Collection and Reconstruction17min
Helical Tubes3min
Farewell2min
4 leituras
Concept Check Questions: Introduction: 2-D Crystallography and Sample Prep10min
Concept Check Questions: Fourier Transform of a 2-D Crystal10min
Concept Check Questions: Data Collection and Reconstruction10min
Concept Check Questions: Helical Tubes10min
4.9
42 avaliaçõesChevron Right

Melhores avaliações

por LRFeb 19th 2018

Great course. I thought it was presented in a very informative way and i learned a lot about cryo-EM. In fact, it made me want to learn more about it. Thank you.

por ALJul 20th 2016

An excellent introduction to the topic, explaining from the basics to the detail of things. Useful and recommended to anyone in structural biology.

Instrutores

Avatar

Grant J. Jensen

Professor of Biophysics and Biology; Investigator, Howard Hughes Medical Institute
Biology and Biological Engineering

Sobre Caltech – Instituto de Tecnologia da CalifórniaCaltech - Instituto de Tecnologia da Califórnia

Caltech is a world-renowned science and engineering research and education institution, where extraordinary faculty and students seek answers to complex questions, discover new knowledge, lead innovation, and transform our future. Caltech's mission is to expand human knowledge and benefit society through research integrated with education. We investigate the most challenging, fundamental problems in science and technology in a singularly collegial, interdisciplinary atmosphere, while educating outstanding students to become creative members of society....

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