Informações sobre o curso
Welcome ! Welcome to this on-demand MOOC “In the footsteps of Zika… approaching the unknown”. This MOOC has been produced by Université de Genève (www.unige.ch), Institut Pasteur (www.pasteur.fr), Université Paris Descartes (www.parisdescartes.fr) and Centre Virchow-Villermé (virchowvillerme.eu). With the help of the intervention of faculty members and international experts, we will explore together the recent Zika phenomenon, a previously rare benign virus that recently turned unexpectedly into the limelight when on the 1st of February 2016 it was declared by the WHO as a Public Health Emergency of International Concern. As this outbreak is still ongoing and under close investigation, this MOOC has the opportunity to be an open learning experience that will follow the marked developments and new discoveries over time. This MOOC will bring you to the heart of the Zika outbreak and invite you to this adventure in uncharted territories. Moreover, we invite you to join the interactive dialogue among participants and facilitators through a community of practice, which promotes questions, critical thinking, participatory learning, as well as interrelated and ongoing collaborative information. Let us learn hand in hand all together to go further in finding clues and eventually solutions! Course description This interdisciplinary course is divided into 8 modules available in 4 languages (subtitles in English, French, Portuguese, Spanish). Each module is organized around a central topic that will help those who take the course to develop their skills and knowledge. Each module provides - interviews with specialists - quizes - recommended readings - online videos and web links. This MOOC will cover a range of topics, such as epidemiology, historical and geographical dispersion of the virus and its vectors through globalization and climate change, its modes of transmission, but also the symptoms, diagnosis and treatment. The different types of preventive measures will be also covered. A special module will focus on possible neurological adverse effects such as the risk for birth defects (microcephaly) in pregnant women, while another one will examine the peripheral nerve paralysis called the Guillain-Barré syndrome. The fact that Zika presents a significant threat to political and economic stabilities and thus reinforces social inequity through South America will be addressed. The revolution in cultural, religious, and legal norms in front of the expansion of Zika will be also debated. Finally, the last two modules will state the role, recommendations and response measures of policy makers and public health organizations under the light of medias.
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Intermediate Level

Nível intermediário

Clock

Aprox. 10 horas restantes

Sugerido: 5 hours
Comment Dots

English

Legendas: English, French, Portuguese (Brazilian), Spanish
Globe

curso 100% online

Comece imediatamente e aprenda em seu próprio cronograma.
Intermediate Level

Nível intermediário

Clock

Aprox. 10 horas restantes

Sugerido: 5 hours
Comment Dots

English

Legendas: English, French, Portuguese (Brazilian), Spanish

Syllabus - What you will learn from this course

1

Section
Clock
1 hour to complete

Introducing Zika virus, its vectors and its hosts

Module 1 introduces Zika virus as a whole. In this module you will increase your knowledge about the virus, its life cycle, its possible mutation, and its transmission patterns through different vectors and hosts (mosquitoes and human beings). You will learn also about its discovery and the possible origin of the current outbreak that started in Brazil and spread out through South America. Finally, we will discover together the strategy developed by this virus to develop and evolve to survive. Prof. Duane Gubler will start by talking about the Emergence of Zika virus and its different hosts and vectors, followed by Dr. Anna-Bella Failloux who will make you discover the cycle of Zika virus and its vectors, all travelling together. Finally, Dr. Maria Van Kerkhove will close this module by covering the sexual transmission of Zika virus and its persistency in body fluids. ...
Reading
5 videos (Total 36 min), 3 readings, 1 quiz
Video5 videos
1.1 Emergence of Zika virus and its different hosts and vectors - Interview with Prof. Duane Gubler8m
1.2 Cycle of Zika virus and its vector-travelling togetherInterview with Dr. Anna-Bella Failloux8m
1.3 What about sexual transmission of Zika virus and persistency? - Interview with Dr. Maria Van Kerkhove2m
Extra - Multi Aedes: mosquito in many places and host of many viruses - Interview with Prof. Patrice Bourée3m
Reading3 readings
Helpful websites regarding the Zika phenomenon10m
Recommended readings10m
Recommended video links10m
Quiz1 practice exercises
Introducing Zika virus, its vectors and its hosts14m

2

Section
Clock
1 hour to complete

Following the tracks of Zika virus

Module 2 relates how Zika virus left the remote African forests towards new destinations across the world partly by globalization and climate change. In this module you will increase your knowledge about the developing of a “love story” with human beings through globalisation. You will also learn how shifts in precipitation levels and temperature caused by climate change, and notably el Niño and la Niña phenomenons, may result into increased survival and/or migration of the virus through vectors into previously non-endemic geographic areas outside the tropical areas. You will also get better knowledge in the characteristics of the recent Zika outbreak in Brazil by local specialists. Dr. Frédéric Simard will start with the relationship between globalization and increased mosquito preference for humans. Then Joint Prof. Aline Philibert and Prof. Antoine Flahault will show you how climate changes can be indirectly and/or directly related to the transmission of Aedes and then Zika virus. Finally, Prof. Aluisio Cotrim Segurado and Prof. Paolo Zanotto of the University of São Paulo will describe the emergence of the outbreak as well as risks and challenges associated with....
Reading
6 videos (Total 28 min), 2 readings, 1 quiz
Video6 videos
2.2 Climate, vectors, and virus: a long-term love story - Interview with Ass. Prof. Aline Philibert8m
2.3 El Niño or La Niña may influence Aedes distribution time - Interview with Prof. Antoine Flahault4m
2.4 Introduction of Zika outbreak in Brazil - Interview with Prof. Aluisio Cotrim Segurado4m
2.5 Particularities of Zika introduction in Brazil - Interview with Prof. Paolo Zanotto2m
Extra - Networking between laboratories to better counteract Zika virus - Interview with Prof. Paolo Zanotto3m
Reading2 readings
Recommended readings10m
Recommended video links10m
Quiz1 practice exercises
Following the tracks of Zika virus14m

3

Section
Clock
1 hour to complete

Prevention and control

Module 3 presents the different types of vector prevention and control. You will get knowledge on the history of vector control and the lessons we have learnt over time. You will also be taught about large-scale control programmes that are now taking place to eradicate mosquitoes in many parts of the world. Beside the common use of insecticides you will explore one new “ecological” technology based on a bacteria that live within the mosquito Aedes. Prof. James Webb will start by talking about the history of vector control and eradication over time. Then, Dr. Frédéric Simard will explain who should be targeted first to prevent vector and virus transmission. You will explore with Prof. John Vontas the molecular analysis of insecticide resistance in major mosquito vectors from mechanisms to resistance management. Finally, Prof. Scott O’Neill will explain you the new and ecofriendly technology of vector control with the Wolbachia bacteria....
Reading
7 videos (Total 37 min), 2 readings, 1 quiz
Video7 videos
3.2 Who and how to protect the persons at the frontline of virus emergence? - Interview with Dr. Frédéric Simard2m
3.3 How can we protect ourselves from Zika? - Interview with Prof. Patrice Bourée2m
3.4 Molecular analysis of insecticide resistance in major mosquito vectors: from mechanisms to resistance management - Interview with Prof. John Vontas12m
3.5 Wolbachia infections in mosquitoes to control Zika - Interview with Prof. Scott O'Neill7m
Extra - Extra activities to better prevent and care epidemics in French Guyana - Interview with Prof. Patrice Bourée1m
Extra - New research on vector control - Interview with Ass. Prof. John Vontas3m
Reading2 readings
Recommended readings10m
Recommended video links10m
Quiz1 practice exercises
Prevention and control14m

4

Section
Clock
1 hour to complete

Symptoms, diagnosis and treatment

This module addresses symptoms, diagnosis and treatment regarding Zika infection. You will discover the challenges related to the two main types of diagnoses, clinical and biochemical (molecular or serological) diagnoses. You will learn that most cases are asymptomatic cases and this causes an issue to forecast virus origin and its transmission to new areas. You will also learn that currently licenced vaccines or medicines to treat Zika are missing. For now, treatment consists of relieving pain, fever, and any other symptoms. Prof. Patrice Bourée will start by listing the known symptoms and diagnosis. You will learn with Prof. Laurent Kaiser about the paradox between the limitation in clinical investigation and the strong technology currently available. Dr. Maria Van Kerkhove will explain you the different types of diagnoses and their limitations. Prof. Ester Sabino will tell you the diagnostic challenges they experienced at the beginning of the Zika outbreak in Brazil. Finally, Dr. Paulo Lee Ho and Dr. In-Kyu Yoon will close the module by telling you how the race is on to develop a Zika vaccine....
Reading
6 videos (Total 27 min), 2 readings, 1 quiz
Video6 videos
4.2 Paradox between strong technology and limitation in clinical investigation - Interview with Prof. Laurent Kaiser6m
4.3 Challenges for clinical and biochemical diagnosis - Interview with Dr. Maria Van Kerkhove1m
4.4 Diagnostic challenges during Zika epidemic in Brazil - Interview with Prof. Ester Sabino3m
4.5 Vaccine, where are we? - Interview with Dr. Paulo Lee Ho5m
4.6 Experience from Dengue vaccine, a blessing for Zika research - Interview with Dr. In-Kyu Yoon3m
Reading2 readings
Recommended readings10m
Recommended video links10m
Quiz1 practice exercises
Symptoms, diagnosis and treatment14m

5

Section
Clock
1 hour to complete

Zika and neurological adverses effects

This module addresses what is known and what is unknown about the neurological adverse effects of Zika virus, especially based on observations and research studies carried out in French Polynesia and in Brazil. In this module you will gain knowledge about the association between Zika infection in mothers and microcephaly in foetus in Brazil as well as the increased Guillain-Barré Syndrome in adults during the Zika outbreak in French Polynesia in 2013-2014. Prof. Olivier Picone, gynecologist-obstetrician, will explain the mechanisms of Zika infection and its health consequences. Dr. Patricia Jungmann will present us the race against time to understand the increased of microcephaly cases in Northeastern Brazil at the beginning of the outbreak and how doctors and scientists worked hand in hand to find clues to better understand the phenomenon. You will learn how the fear of microcephaly is becoming a nightmare for pregnant Brazilian women or those who would like to fall pregnant with Prof. Aluisio Cotrim Segurado and Prof. Laura Rodrigues. Prof. Tom Solomon and Prof. Arnaud Fontanet will close the module with the neurological effects of Zika in adults, notably regarding the Guillain-Barré syndrome that recently occurred in many infected cases in French Polynesia....
Reading
7 videos (Total 40 min), 2 readings, 1 quiz
Video7 videos
5.2 How we discovered Zika was related to microcephaly in North-eastern Brazil - Interview with Dr. Patricia Jungmann6m
5.3 Burden of Zika laid on the shoulders of Brazilian women - Interview with Prof. Aluisio Cotrim Segurado1m
5.4 A new nightmare for pregnant women in Brazil - Interview with Prof. Laura Rodrigues9m
5.5 Neurologic Complications of Flaviviruses - Interview with Prof. Tom Solomon3m
5.6 Zika and Guillain-Barré Syndrome: case of French Polynesia - Interview with Prof. Arnaud Fontanet7m
Extra - Opportunity of online university training on virology and gynecology - Interview with Prof. Olivier Picone1m
Reading2 readings
Recommended readings10m
Recommended video links10m
Quiz1 practice exercises
Zika and neurological adverses effects14m

6

Section
Clock
1 hour to complete

Inequity in front of Zika exposure and outcomes

The module 6 presents the inequity existing between poor and wealthy communities in the fight against Zika virus in Brazil and South America. You will learn that decades of rapid and chaotic urbanization have left many impoverished areas without basic sanitation, putting the poor at far greater risk of contracting Zika and other mosquito-borne viruses. Aside from the dangers that come with the spread of this disease, you will learn how inequity is aggravated by difference of access to health care, socio-economical support, and limited reproductive rights in this region. Finally, the module will make you better understand the fact that women’s rights and reproductive issues in the South America landscape are highly controversial topics. You will also better understand how Zika virus is starting a legal revolution regarding abortion right, while it has always been largely illegal and seen as a taboo in many countries in South America. Dr. Serge Rabier will start by describing the anthropological perspective related to the health crisis of Zika in South America. You will learn with Prof. Helena Ribeiro the inequity regarding exposure to virus in favelas and elsewhere. Dr. Ester Sabino will talk about contraception and abortion challenges for women in Brazil. Finally, Dr. Flávia Bulegon Pilecco will close the module by telling us how Zika is fuelling a new debate over legal and safe abortion in South America. ...
Reading
4 videos (Total 31 min), 2 readings, 1 quiz
Video4 videos
6.2 The rapid increase of Aedes in poor urban settings in Northern Brazil - Interview with Prof. Helena Ribeiro8m
6.3 Abortion and contraception challenges for women in Brazil - Interview with Dr. Ester Sabino2m
6.4 Relation between microcephaly and sexual reproduction in Brazil - Interview with Dr. Flávia Bulegon Pilecco8m
Reading2 readings
Recommended readings10m
Recommended video links10m
Quiz1 practice exercises
Inequity in front of Zika exposure and outcomes12m

7

Section
Clock
1 hour to complete

How do deal with Zika: WHO and international health organizations' perspectives

The module 7 explains how the recent Zika outbreak, the cluster of microcephaly cases and neurological events occurring at the same time and place (mainly Brazil) resulted in a public health emergency of international concern. You will learn about the role and duties of international organizations and the fact that this is the first time the global scientific community commits to sharing data on Zika. You will be exposed by discussions related to the fact that WHO and other partners seek to learn from their failure regarding the Ebola crisis, after they were heavily criticised for their slow response. Prof. David Heymann will start by explaining how Zika became a public health emergency of international concern. Dr. Marie-Paule Kieny, Dr. Sylvie Briand and Dr. In-Kyu Yoon will debate for us on the roles and duties of international organizations to ensure that proportionate actions are taken and what lessons we learnt from the past outbreaks....
Reading
5 videos (Total 27 min), 2 readings, 1 quiz
Video5 videos
7.2 Drawing lessons from Ebola to prepare roadmap for future epidemicsInterview with Dr. Marie-Paule Kieny5m
7.3 Zika and international health regulations - Interview with Dr. Sylvie Briand6m
7.4 Working all together to reach the unknownInterview with Dr. Maria Van Kerkhove2m
7.5 How lessons learnt from the past can bring us near to the unknown of Zika - Interview with Dr. In-Kyu Yoon5m
Reading2 readings
Recommended readings10m
Recommended video links10m
Quiz1 practice exercises
How do deal with Zika: WHO and international health organizations' perspectives12m

8

Section
Clock
2 hours to complete

The Zika phenomenon through medias and economical & political challenges

In this module you will better understand how Zika virus has been controlled or uncontrolled by the medias in the era of social networks, and what could be the role of the medias regarding prevention and control of the Zika disease in South and Latin America.The module 8 reports how the Zika phenomenon has been hitting the headlines over the past months. You will learn that aside from the health risks it poses, Zika also affects economy and politics in South America. You will be exposed to the economic adverse effects of Zika on touristic hotspots in Latin America and on the coming Olympic games in Brazil. Dr. Paul Benkimoun will start by making a summary of what has been reported in headlines in the past few months. Dr. Jean-Yves Nau will make an analysis of the different ingredients the Zika phenomenon is constructed of in the news, such as health, politics and economy. Margaret Harris will tell us the importance of the transparency and the adequacy of the messages that should be disseminated to the public. Dr. Anneliese Depoux will let us know what are the raise of awareness via social networks. Finally, Dr. Josselin Thuilliez will close the module by debating on economical issues related to the Zika phenomenon....
Reading
8 videos (Total 61 min), 5 readings, 1 quiz
Video8 videos
8.2 Message and origin of information - Interview with Dr. Paul Benkimoun5m
8.3 A complete picture of the Zika phenomenon through medias - Interview with Dr. Jean-Yves Nau14m
8.4 Zika, medias and transparency - Interview with Margaret Harris6m
8.5 Popular involvement and raise of public awareness - Interview with Dr. Anneliese Depoux6m
8.6 Prevention and popular education parts of the public sphere: various types of commitments - Interview with Dr. Anneliese Depoux6m
8.7 Economic dimensions of the Zika phenomenon - Interview with Dr. Josselin Thuilliez8m
Extra - New app of WHO for Zika - Interview with Margaret Harris2m
Reading5 readings
References for video "Popular involvement and raise of public awareness"10m
References for video "Prevention and popular education parts of the public sphere: various types of commitments"10m
References for video "Extra - New app of WHO for Zika"10m
Recommended readings10m
Recommended video links10m
Quiz1 practice exercises
The Zika phenomenon through medias and economical & political challenges14m
4.7

Top Reviews

By JVDec 2nd 2016

Excelente curso, se aprenden muchas perspectivas de la patologia y de los vectores que propagan a la misma, en mi pais existen muchos casos de infeccion de zika, por lo que me resulto de gran ayuda.

By CSMar 31st 2017

Buenos materiales, realización y orientación multidisciplinar de una realidad tan compleja como la constituida por el virus Zika

Instructors

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Antoine Flahault

Professor of Public Health and Director of the Institute of Global Health (Faculty of Medicine, University of Geneva) and co-Director of Centre Virchow-Villermé (Université Paris Descartes)
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Arnaud Fontanet (in Partnership with UNIGE)

Director Center for Global Health – Head of Emerging Diseases Epidemiology Unit
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Henri-Jean Philippe (In Partnership with UNIGE)

Gynecologist, Obstetrician - Head of Department at the Hôpital Cochin

About University of Geneva

Founded in 1559, the University of Geneva (UNIGE) is one of Europe's leading universities. Devoted to research, education and dialogue, the UNIGE shares the international calling of its host city, Geneva, a centre of international and multicultural activities with a venerable cosmopolitan tradition....

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