About this course: Kidney transplantation is a major advance of modern medicine which provides high-quality of life for patients with end-stage renal disease. What used to be an experimental, risky, and very limited treatment option more than 50 years ago is now routinely performed in many countries worldwide. The number of renal transplants is expected to rise sharply in the next decade since the proportion of patients with end stage renal disease is increasing. Are you interested in clinical kidney, pancreas and islet transplantation? If you are a (bio) medical student or a health care professional who works in the (pre) clinical transplant field this might be the course for you. This course is also for anyone interested in the research and knowledge on clinical transplantation. The course will be taught by a multidisciplinary team of transplant professionals and will give you the state of the art updates. It is divided in 4 modules: 1) Before the transplant 2) The surgical procedures and the challenged patient, including the patient with diabetes 3) Early challenges 4) Late challenges after transplantation. The offered modules will include lectures, interactive patient cases, 3D movies, interviews with well-known experts and with patients and a donor, a serious game to increase knowledge of the field and of course an active forum. Become an expert and join us! The course is endorsed by The European Society of Organ Transplantation (ESOT), The International Society of Nephrology (ISN) and The Transplantation Society (TTS).
Who is this class for: Anyone with a general interest in Clinical Kidney Transplantation, both beginners and professionals. This course is free, and will remain free for participants. You can purchase a certificate.
Created by: Universiteit Leiden, Leiden University Medical Center
Taught by: Marlies Reinders, Dr.
LUMC, Department of Nephrology and Transplantation
Taught by: Frans Claas, Professor
LUMC, Department of Immunohaematology and Blood Transfusion
Taught by: Cees van Kooten , Professor
LUMC, Department of Nephrology and Transplantation
Taught by: Sebastiaan Heidt, Dr.
LUMC, Department of Immunohaematology and Blood Transfusion
Taught by: Volkert Huurman, Dr.
LUMC, Department of Transplant Surgery
Taught by: Hans de Fijter, Professor
LUMC, Department of Nephrology and Transplantation
Taught by: Eelco de Koning , Professor
LUMC, Department of Nephrology and Transplantation and Endocrinology and Metabolism
Taught by: Andre Baranski, Dr.
LUMC, Department of Transplant Surgery
Taught by: Ton Rabelink, Professor
LUMC, Department of Nephrology and Transplantation
Taught by: Aiko de Vries, Dr.
LUMC, Department of Nephrology and Transplantation
Taught by: Jan Nico Bouwes Bavinck, Dr.
LUMC, Department of Dermatology
Taught by: Leo Visser , Professor
LUMC, Department of Infectious Diseases
Taught by: Ingeborg Bajema, Dr.
LUMC, Department of Pathology
| Level | Intermediate |
| Commitment | 4 weeks of study, 4-6 hours a week |
| Language | English |
| How To Pass | Pass all graded assignments to complete the course. |
| User Ratings |
Syllabus
WEEK 1
Welcome to the course
Great that you are joining us! In this course you will learn about clinical kidney, pancreas and islet transplantation and its challenges. Before you start with studying we invite you first go through our introduction module and introduce yourself in the forum to meet your fellow learners. If you encounter any difficulties while studying, please let us know in the forum. For technical difficulties or questions regarding the course certificate, you can always contact the Coursera Learner Helpdesk. Good luck & we hope you enjoy studying in this course!
1 video, 5 readings
- Video: Trailer Clinical Kidney Transplantation
- Reading: About us: Introduction to the Team
- Reading: Welcome to Leiden University
- Reading: Tips for studying online
- Reading: Being successful in an international virtual learning environment
- Reading: Behaving in an academic way
- Discussion Prompt: Introduce yourself
Before the Transplant
Welcome to this first module of the course! We will answer important questions before transplantation. These include: why is transplantation the preferred option for patients with end stage renal disease? What are the immunological barriers for transplantation? And what are the selection criteria before transplantation? Unique 3D movies about the different immunological tests will help you to understand the concepts. There are also optional lectures, including a fascinating movie about the Eurotransplant allocation system and patient/donor interviews. At the end of the module we will link the contents you have learned to clinical patient cases, patient - donor interviews and a quiz. You can find each other on the discussion forum. With the e-tivities you can apply your knowledge. In the honors lessons more in depth immunological testing and pre transplant screening can be obtained. The lesson also includes peer reviews about important preclinical questions. Have fun and good luck with the first module!
11 videos, 4 readings
- Video: Short Introduction
- Video: The Kidney in Health and Disease
- Video: Options if Kidneys Fail
- Video: Immunogenetics
- Video: Introduction to the Immune System
- Video: The Humoral Immune System
- Video: Histocompatibility
- Discussion Prompt: E-tivity: Which Donor do you choose?
- Video: Cases from Daily Practice - Patient Selection
- Video: Eurotransplant Company Film 'More than a Match'
- Video: Interview: Transplant Recipient and Donor: Part 1
- Reading: Glossary
- Reading: References
- Video: Epitopes
- Reading: HLA Epitope Matching is the Future
- Reading: HLA Antibody Detection: Not All Antibodies are the Same
- Discussion Prompt: E-tivity: Which Strategy would you choose for this Highly Sensitized Patient?
Graded: Check your knowledge
Graded: Advise your Colleague: a Pretransplantation Question
Graded: Check your knowledge
WEEK 2
The Procedure and the Patient
Now you know the factors of importance before transplantation, including the immunological barriers and important aspects for patient selection, we can focus on challenged patient groups and on surgical procedures. What does a kidney, pancreas and islet transplantation surgical procedure look like? What is important? And what are the key aspects in elderly patients, patients with diabetes and immunological challenged patients. We have unique visulisations and a game about a patient case. Advanced readings will invite you to look at the different subjects in more depth. At the end of the module there are interviews about a patient with diabetes and the transplant recipient and donor to illustrate the impact of life. You can discuss patient cases on the forum together with your peers. In the honors lesson you can apply knowledge about more in depth immunological, surgical and metabolic challenges and living kidney donation. Let’s start and we hope you will enjoy this module.
14 videos, 6 readings
- Video: Short Introduction
- Video: Immunological Challenged Patient: ABO Incompatible Transplants
- Video: Immunological Challenged Patient: Highly Sensitized Patient
- Video: The Diabetic Patient
- Video: The Elderly Patient
- Video: Organ Procurement and Preservation
- Video: Kidney Transplant Surgery
- Video: Simultaneous Pancreas Kidney & Islet Transplantation
- Video: A: Cases from Daily Practice: Different Choices for Different Diabetic Patients
- Video: B: Cases from Daily Practice: Different Choices for Different Diabetic Patients
- Reading: Serious Game: A Patient with Immunological Challenges
- Discussion Prompt: E-tivity: Which treatment do you advise?
- Video: Interview: Patient with Diabetes
- Video: Interview: Transplant Recipient and Donor: Part 2
- Reading: Glossary
- Reading: References
- Video: B Cell Replacement and Diabetes Type II
- Video: Surgical Challenged Patients
- Reading: Highly Sensitized Patients: The AM Program
- Reading: Additional Challenged Transplant Recipients
- Reading: Living Kidney Donation
- Discussion Prompt: E-tivity: Do you accept this donor?
Graded: Check your knowledge
Graded: Check your knowledge
WEEK 3
Early Challenges in Transplantation
You are now familiar with the basic knowledge about challenges in transplant recipients and the surgical transplant procedures. Once the transplantation has been successful, it doesn’t mean everything is stable. What are actually the graft survival data? Which challenges do we face in the first months? How can we tackle these challenges? 3D movies about early surgical challenges and about the targets for immunosuppressives, including cell therapy, will help you to understand the concepts. In addition, we invite you to master the advanced knowledge and to give your opinion in the patient cases in the forum. There is also a serious game about a patient case. Can you solve the challenges? And can you think of a scenario for the game and help us with building? We will make a game of the best scenario, which will be incorporated in the course. In the honors lesson you can learn in more detail about immunological concepts, including the complement system. A patient case will help to show you the importance of this knowledge. Good luck with this module and happy learning!
12 videos, 9 readings
- Video: Introduction & Overview of Early Challenges in Transplantation
- Video: Surgical Challenges in the Early Period
- Video: Ischemia Reperfusion Injury
- Video: Cellular Rejection
- Video: Antibody Mediated Rejection
- Video: Immune Suppression
- Video: Novel Therapeutics: Cell Therapy after Transplantation
- Discussion Prompt: Advanced e-tivity - MSC therapy in the transplant recipient
- Video: Cases from Daily Practice A - Patient Cases with Early Challenges
- Video: Cases from Daily Practice B - Patient Cases with Early Challenges
- Reading: Serious Game: Interactive Patient Case
- Peer Review: Design the next game
- Video: Interview Transplant Recipient & Donor: Part 3
- Reading: Optional - Immunesuppressive Regimens and Toxicity Profiles
- Reading: Biomarkers
- Reading: Therapeutic drug monitoring of immunosuppressive drugs
- Discussion Prompt: Etivity: Personalized dosing: what is your advice
- Discussion Prompt: Etivity: What is your therapeutic advice?
- Reading: Glossary
- Reading: References
- Video: The Complement System and Transplantation
- Video: Cases from Daily Practice: Patient Case with an Early Challenge
- Reading: A closer Look at Antibody Mediated Rejection
- Reading: Innate Immunity and Impact on Transplantation
- Reading: Molecular Insights into Cellular Rejection
- Discussion Prompt: Advanced e-tivity - Which cytokine is target of the next drug?
Graded: Check your knowledge
Graded: Check your knowledge
WEEK 4
Late Challenges in Transplantation
Now you’ve learned about the challenges in the early period after transplantation. But what about the late period? What is the long term patient and allograft survival? Have we improved in the last decades? What are the main causes for morbidity and mortality? And can we reach tolerance in the future? We invite you to give your opinion in the patient cases and to discuss it on the forum. There are also advanced readings to look at additional subjects, including recurrence of the kidney disease after transplantation, the organization of dermatological care for the transplant recipient and the role of the patient himself in the whole process. The interview about tolerance gives you insight why pregnancy is of interest to understand the concept of tolerance and which steps have been made from lab research to a clinical protocol. In the honors lesson late challenges will be discussed in more detail, with a focus on infections, recurrence of the kidney disease after transplantation and tolerance. Have fun and good luck with this last module.
12 videos, 5 readings, 3 practice quizzes
- Video: Introduction & Overview of Late Challenges in Transplantation
- Video: Infections: Overview and CMV infection
- Video: Infections: BK and EBV infection
- Video: Malignancies
- Reading: Pneumocystis jirovecii
- Discussion Prompt: E-tivity - How can we prevent Pneumocystis Jirovecii Pneumoniae?
- Video: Late Challenges after Pancreas and Islet Transplantation
- Video: Post Transplant Diabetes Mellitus
- Video: Cardiovascular Disease
- Discussion Prompt: E-tivity - Why do many transplant patients suffer from obesity?
- Video: Tolerance: Interview with Prof. Claas (LUMC) and Prof. Wood (Oxford)
- Video: Cases from Daily Practice A - Patient Cases with Late Challenges
- Video: Cases from Daily Practice B - Patient Cases with Late Challenges
- Discussion Prompt: E-tivity - Can the patient himself influence allograft survival
- Practice Quiz: Patient Case 1: Enhanced Glucose after SPK
- Practice Quiz: Patient Case 2: Hyperglycemia after Islet Transplantation
- Practice Quiz: Patient Case 3: A Complication after Pancreas-alone Transplantation
- Reading: Glossary
- Reading: References
- Video: Recurrence of Kidney Disease after Transplantation
- Video: Vaccination and Transplantation
- Reading: Skin Diseases after Transplantation and Dermatological Aftercare
- Reading: Tolerance in more Detail
- Discussion Prompt: E-tivity: How can we reach tolerance?
Graded: Check your knowledge
Graded: Advise your Colleague: Donor Derived Infections
Graded: Check your knowledge
Final Quiz
We hope you have enjoyed all the modules. Good luck with the final quiz!
If you are interested in an intensive course about transplantation go to the course resources.
Graded: Final Exam
Graded: Final Honours Exam
FAQs
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Universiteit Leiden
Leiden University is one of Europe's foremost research universities. This prominent position gives our graduates a leading edge in applying for academic posts and for functions outside academia.
Leiden University is the oldest university in the Netherlands. It was founded in February 1575, as a gift from William of Orange to the citizens of Leiden after they had withstood a long siege by the Spanish. Our motto is: Praesidium Libertatis — Bastion of Liberty.
Leiden University Medical Center
Ratings and Reviews
It is a great course with great teachers. I really liked to do this course. The support material and videos are excellent.
The course benefits from the excellent quality of the lectures by superb staff of the LUMC. The videos and images were of high quality and irrefutably aided in the understanding of the difficult field of transplantation immunology. I highly recommend following this course. The pace was just right and because the user can decide on his/her own planning, it can easily be combined with other activities. The tests were of varying difficulty, the final test clearly being much more difficult than the other tests combined.
Excellent course materials & presentations
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sh
this is very excellent course , i learnt a lot of information and it very informative and beneficial course
thanks alot