Kidney transplantation is a major advance of modern medicine which provides high-quality of life for patients with end-stage renal disease. What used to be an experimental, risky, and very limited treatment option more than 50 years ago is now routinely performed in many countries worldwide. The number of renal transplants is expected to rise sharply in the next decade since the proportion of patients with end stage renal disease is increasing.
Are you interested in clinical kidney, pancreas and islet transplantation? If you are a (bio) medical student or a health care professional who works in the (pre) clinical transplant field this might be the course for you. This course is also for anyone interested in the research and knowledge on clinical transplantation. The course will be taught by a multidisciplinary team of transplant professionals and will give you the state of the art updates.
It is divided in 4 modules:
1) Before the transplant
2) The surgical procedures and the challenged patient, including the patient with diabetes
3) Early challenges
4) Late challenges after transplantation.
The offered modules will include lectures, interactive patient cases, 3D movies, interviews with well-known experts and with patients and a donor, a serious game to increase knowledge of the field and of course an active forum. Become an expert and join us!
The course is endorsed by The European Society of Organ Transplantation (ESOT), The International Society of Nephrology (ISN) and The Transplantation Society (TTS).
This MOOC has been accredited for Continuing Medical Education (CME). Health care professionals who works in the (pre) clinical transplant field, other health care professionals and general practitioners can obtain CME credit at 'LUMC-Boerhaave CME' upon passing the course. For more information we like to refer to the "Additional introduction for obtaining CME credit" module in week 1 of the course
For another interesting course on organ donation and transplantation, see Organ Donation: From Death to Life from Cape Town University https://www.coursera.org/learn/organ-donation
Clinical Kidney, Pancreas and Islet Transplantation
oferecido por
Universidade de Leiden
Leiden University Medical Center
Universidade de Leiden
Programa - O que você aprenderá com este curso
Semana
1Welcome to the course
Great that you are joining us! In this course you will learn about clinical kidney, pancreas and islet transplantation and its challenges. Before you start with studying we invite you first go through our introduction module and introduce yourself in the forum to meet your fellow learners. Medical professionals can receive Continuing Medical Education (CME) credit for this course. Information on CME credit and how to obtain credit can be found in our CME credit module. If you encounter any difficulties while studying, please let us know in the forum. For technical difficulties or questions regarding the course certificate, you can always contact the Coursera Learner Helpdesk. Good luck & we hope you enjoy studying in this course!
1 vídeo (total de (Total 2 mín.) min), 9 leituras
1 vídeos
9 leituras
About us: Introduction to the Team5min
Welcome to Leiden University5min
Complete our short survey10min
Tips for studying online5min
Being successful in an international virtual learning environment5min
Behaving in an academic way5min
CME information10min
How to apply for CME credit10min
CME FAQs10min
Before the Transplant
Welcome to this first module of the course! We will answer important questions before transplantation. These include: why is transplantation the preferred option for patients with end stage renal disease? What are the immunological barriers for transplantation? And what are the selection criteria before transplantation? Unique 3D movies about the different immunological tests will help you to understand the concepts. There are also optional lectures, including a fascinating movie about the Eurotransplant allocation system and patient/donor interviews. At the end of the module we will link the contents you have learned to clinical patient cases, patient - donor interviews and a quiz. You can find each other on the discussion forum. With the e-tivities you can apply your knowledge. In the honors lessons more in depth immunological testing and pre transplant screening can be obtained. The lesson also includes peer reviews about important preclinical questions. Have fun and good luck with the first module!
11 vídeos (total de (Total 79 mín.) min), 4 leituras, 3 testes
11 videos
The Kidney in Health and Disease5min
Options if Kidneys Fail5min
Immunogenetics7min
Introduction to the Immune System6min
The Humoral Immune System6min
Histocompatibility7min
Cases from Daily Practice - Patient Selection7min
Eurotransplant Company Film 'More than a Match'13min
Interview: Transplant Recipient and Donor: Part 110min
Epitopes6min
4 leituras
Glossary10min
References5min
HLA Epitope Matching is the Future30min
HLA Antibody Detection: Not All Antibodies are the Same30min
2 exercícios práticos
Check your knowledge30min
Check your knowledge10min
Semana
2The Procedure and the Patient
Now you know the factors of importance before transplantation, including the immunological barriers and important aspects for patient selection, we can focus on challenged patient groups and on surgical procedures. What does a kidney, pancreas and islet transplantation surgical procedure look like? What is important? And what are the key aspects in elderly patients, patients with diabetes and immunological challenged patients. We have unique visulisations, 360 virtual reality videos and a game about a patient case. Advanced readings will invite you to look at the different subjects in more depth. At the end of the module there are interviews about a patient with diabetes and the transplant recipient and donor to illustrate the impact of life. You can discuss patient cases on the forum together with your peers. In the honors lesson you can apply knowledge about more in depth immunological, surgical and metabolic challenges and living kidney donation. Let’s start and we hope you will enjoy this module.
14 vídeos (total de (Total 111 mín.) min), 7 leituras, 3 testes
14 videos
Immunological Challenged Patient: ABO Incompatible Transplants6min
Immunological Challenged Patient: Highly Sensitized Patient6min
The Diabetic Patient10min
The Elderly Patient6min
Organ Procurement and Preservation9min
Kidney Transplant Surgery7min
Simultaneous Pancreas Kidney & Islet Transplantation15min
A: Cases from Daily Practice: Different Choices for Different Diabetic Patients5min
B: Cases from Daily Practice: Different Choices for Different Diabetic Patients6min
Interview: Patient with Diabetes14min
Interview: Transplant Recipient and Donor: Part 24min
B Cell Replacement and Diabetes Type II11min
Surgical Challenged Patients6min
7 leituras
Introduction to Watching 360 VR Videos10min
Serious Game: A Patient with Immunological Challenges30min
Glossary10min
References5min
Highly Sensitized Patients: The AM Program30min
Additional Challenged Transplant Recipients30min
Living Kidney Donation30min
2 exercícios práticos
Check your knowledge30min
Check your knowledge20min
Semana
3Early Challenges in Transplantation
You are now familiar with the basic knowledge about challenges in transplant recipients and the surgical transplant procedures. Once the transplantation has been successful, it doesn’t mean everything is stable. What are actually the graft survival data? Which challenges do we face in the first months? How can we tackle these challenges? 3D movies about early surgical challenges and about the targets for immunosuppressives, including cell therapy, will help you to understand the concepts. In addition, we invite you to master the advanced knowledge and to give your opinion in the patient cases in the forum. There is also a serious game about a patient case. Can you solve the challenges? And can you think of a scenario for the game and help us with building? We will make a game of the best scenario, which will be incorporated in the course. In the honors lesson you can learn in more detail about immunological concepts, including the complement system. A patient case will help to show you the importance of this knowledge. Good luck with this module and happy learning!
12 vídeos (total de (Total 95 mín.) min), 9 leituras, 3 testes
12 videos
Surgical Challenges in the Early Period5min
Ischemia Reperfusion Injury6min
Cellular Rejection8min
Antibody Mediated Rejection6min
Immune Suppression10min
Novel Therapeutics: Cell Therapy after Transplantation8min
Cases from Daily Practice A - Patient Cases with Early Challenges6min
Cases from Daily Practice B - Patient Cases with Early Challenges6min
Interview Transplant Recipient & Donor: Part 38min
The Complement System and Transplantation11min
Cases from Daily Practice: Patient Case with an Early Challenge7min
9 leituras
Serious Game: Interactive Patient Case30min
Optional - Immunesuppressive Regimens and Toxicity Profiless
Biomarkers40min
Therapeutic drug monitoring of immunosuppressive drugss
Glossary10min
References5min
A closer Look at Antibody Mediated Rejection30min
Innate Immunity and Impact on Transplantation30min
Molecular Insights into Cellular Rejection30min
2 exercícios práticos
Check your knowledge20min
Check your knowledge10min
Semana
4Late Challenges in Transplantation
Now you’ve learned about the challenges in the early period after transplantation. But what about the late period? What is the long term patient and allograft survival? Have we improved in the last decades? What are the main causes for morbidity and mortality? And can we reach tolerance in the future? We invite you to give your opinion in the patient cases and to discuss it on the forum. There are also advanced readings to look at additional subjects, including recurrence of the kidney disease after transplantation, the organization of dermatological care for the transplant recipient and the role of the patient himself in the whole process. The interview about tolerance gives you insight why pregnancy is of interest to understand the concept of tolerance and which steps have been made from lab research to a clinical protocol. In the honors lesson late challenges will be discussed in more detail, with a focus on infections, recurrence of the kidney disease after transplantation and tolerance. Have fun and good luck with this last module.
12 vídeos (total de (Total 96 mín.) min), 5 leituras, 6 testes
12 videos
Infections: Overview and CMV infection8min
Infections: BK and EBV infection7min
Malignancies8min
Late Challenges after Pancreas and Islet Transplantation8min
Post Transplant Diabetes Mellitus8min
Cardiovascular Disease7min
Tolerance: Interview with Prof. Claas (LUMC) and Prof. Wood (Oxford)13min
Cases from Daily Practice A - Patient Cases with Late Challenges5min
Cases from Daily Practice B - Patient Cases with Late Challenges6min
Recurrence of Kidney Disease after Transplantation8min
Vaccination and Transplantation8min
5 leituras
Pneumocystis jirovecii10min
Glossary10min
References5min
Skin Diseases after Transplantation and Dermatological Aftercare30min
Tolerance in more Detail30min
5 exercícios práticos
Check your knowledge30min
Patient Case 1: Enhanced Glucose after SPK15min
Patient Case 2: Hyperglycemia after Islet Transplantation15min
Patient Case 3: A Complication after Pancreas-alone Transplantation15min
Check your knowledge20min
Final Quiz
We hope you have enjoyed all the modules. Good luck with the final quiz!
If you are interested in an intensive course about transplantation go to the course resources.
2 leituras, 2 testes
2 leituras
Complete our short survey10min
Leiden Oxford Transplantation Summerschool10min
2 exercícios práticos
Final Exams
Final Honours Exam16min
50%
comecei uma nova carreira após concluir estes cursos
30%
consegui um benefício significativo de carreira com este curso
11%
recebi um aumento ou promoção
Melhores avaliações
por SW•Dec 27th 2016
Wonderful course. Great instruction on very interesting topics. Videos support learning and a good amount of information every week. Thanks for the organization and delivery of this course.
por AE•May 24th 2017
THE BEST COURSE I have taken in COURSERA\n\nGREAT LECTURERS , BEST VIDEOS, AND VERY ORGANIZED\n\n3D movies are really fantastic\n\nHope to join in future sessions to get better scores
Instrutores
Marlies Reinders
Dr.LUMC, Department of Nephrology and Transplantation
Frans Claas
ProfessorLUMC, Department of Immunohaematology and Blood Transfusion
Cees van Kooten
ProfessorLUMC, Department of Nephrology and Transplantation
Sebastiaan Heidt
Dr.LUMC, Department of Immunohaematology and Blood Transfusion
Volkert Huurman
Dr.LUMC, Department of Transplant Surgery
Hans de Fijter
ProfessorLUMC, Department of Nephrology and Transplantation
Eelco de Koning
ProfessorLUMC, Department of Nephrology and Transplantation and Endocrinology and Metabolism
Andre Baranski
Dr.LUMC, Department of Transplant Surgery
Ton Rabelink
ProfessorLUMC, Department of Nephrology and Transplantation
Aiko de Vries
Dr.LUMC, Department of Nephrology and Transplantation
Jan Nico Bouwes Bavinck
Dr.LUMC, Department of Dermatology
Leo Visser
ProfessorLUMC, Department of Infectious Diseases
Ingeborg Bajema
Dr.LUMC, Department of Pathology
Sobre Universidade de Leiden
Leiden University is one of Europe's foremost research universities. This prominent position gives our graduates a leading edge in applying for academic posts and for functions outside academia.
Leiden University is the oldest university in the Netherlands. It was founded in February 1575, as a gift from William of Orange to the citizens of Leiden after they had withstood a long siege by the Spanish. Our motto is: Praesidium Libertatis — Bastion of Liberty.
Sobre Leiden University Medical Center
Perguntas Frequentes – FAQ
Quando terei acesso às palestras e às tarefas?
Ao se inscrever para um Certificado, você terá acesso a todos os vídeos, testes e tarefas de programação (se aplicável). Tarefas avaliadas pelos colegas apenas podem ser enviadas e avaliadas após o início da sessão. Caso escolha explorar o curso sem adquiri-lo, talvez você não consiga acessar certas tarefas.
O que recebo ao adquirir o Certificado?
Quando você adquire o Certificado, ganha acesso a todo o material do curso, incluindo avaliações com nota atribuída. Após concluir o curso, seu Certificado eletrônico será adicionado à sua página de Participações e você poderá imprimi-lo ou adicioná-lo ao seu perfil no LinkedIn. Se quiser apenas ler e assistir o conteúdo do curso, você poderá frequentá-lo como ouvinte sem custo.
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Existe algum auxílio financeiro disponível?
What are CME credits?
Continuing Medical Education (CME) consists of educational activities that aim to maintain, develop, or increase the knowledge, skills, and professional performance in order to maintain competence and learn about new and developing areas of the medical field. Content for these programs is developed, reviewed, and delivered by faculty who are experts in their individual clinical areas. In various countries, a certain amount of CME-credit hours must be obtained by medical professionals to maintain their licenses.
For this course it is possible to obtain 5, 9 or 13 CME credit points. For more information on how to obtain these points we like to refer to the "Additional introduction for obtaining CME credit" module in week 1 of the course
Can I apply for CME credits if I have already finished the course previously?
Yes, if you have already done the course previously and obtained the Coursera official Course Certificate as proof we encourage you to apply for the CME credits. You can obtain 5 or 9 CME as follows:
1. Sign up for the course at “Boerhaave Continuous Medical Education” (https://www.boerhaavecontinuousmedicaleducation.com/)
2. Upload your Verified Certificate from Coursera (without honors 5 CME or with honors 9 CME). Pay the contribution according to “Boerhaave Continuous Medical Education." They will provide you with the instructions and add the CME credits to GAIA (Dutch participants) and/or provide you with a CME certificate (international participants)
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