The vital signs – heart rate, blood pressure, body temperature, respiration rate, and pain – communicate important information about the physiological status of the human body. In this six-part course we explore the anatomy and physiology underlying the vital signs so that you will develop a systematic, integrated understanding of how the body functions. Relevant body systems are reviewed including cardiovascular and respiratory, followed by explanations of how the function of these systems affects vital signs. We discuss normal ranges, normal variants, and the mechanisms that underlie changes in the objective measurement of vital signs. The course also includes demonstrations of appropriate techniques for measuring vital signs in yourself and others. The course is designed for a broad, general audience but will be particularly interesting for individuals working in healthcare, those considering a career as a healthcare professional, lay caregivers, those with an interest in personal health and fitness, or anyone who simply wants to understand how the body functions.