So the, the reason for
doing semantics cell nuclear transplantation is that by removing
the chromosomes from the egg and replacing them with these adult chromosomes.
You can make an embryonic stem cell line,
which has all the genes of that adult cell.
>> if we could take a stem cell and give it the nuclear material,
the DNA of a patient who has diabetes, and
let that stem cell develop into an insulin producing cell.
We could study the development of that cell,
we could study the processes that lead to the malfunction of that cell.
We could understand how the beta cell works at such a fundamental level,
that we would actually be able to intervene using other kinds of approaches.
So a primary promise of stem cells with regard to diabetes or
any of these other diseases, such as Parkinson's disease or
amyotrophic lateral sclerosis or Alzheimer's disease.
Is that we can create the cell type of interest that has the genetic mark
on it so to speak of an individual who has the disease.
And watch that cell develop, and we can see what the steps in development
are that have gone awry in that individual.
This will provide extraordinary insight that just simply is not available to us,
even by studying patients who we know will have the disease.