Most people know that electrically active cells in nerves, in the heart and in the brain generate electrical currents, and that somehow these result in measurements we all have heard about, such as the electrocardiogram. But how? That is, what is it that happens within the electrically active tissue that leads to the creation of currents and voltages in their surroundings that reflect the excitation sequences timing, and condition of the underlying tissue. This course explores that topic. Rather than being a primer on how to interpret waveforms of any kind in terms of normality or disease, the goal here is to provide insight into how the mechanism of origin actually works, and to do so with simple examples that are readily pictured with simple sketches and one’s imagination, and then moving forward into comparison with experiments and finding outcomes quantitatively.
Bioelectricity: The Mechanism of Origin of Extracellular Potentials
oferecido por
Universidade Duke
Programa - O que você aprenderá com este curso
Semana
1Week 1
A brief history of extracellular measurements, and an example of such a recording. The goal is to understand the amplitudes and time variation of such measurements, as well as learn about some interesting and useful historical events.
3 vídeos (total de (Total 20 mín.) min), 3 leituras, 1 teste
3 videos
Welcome7min
The First Extracellular Measurements5min
Observing Wave Forms Between Human Hands7min
3 leituras
Course Overview10min
Assessments, Grading and Certificates10min
Week 1 Slides10min
1 exercício prático
120min
Semana
2Week 2
A presentation of the cylindrical fiber model of a nerve. The goal is to see how this geometrically simple model of a nerve actually is sufficient to explain complex bioelectric events within and around electrically active tissue. One learns that currents are driven forward by voltages across cell membranes,. Current loops are created, with some parts of the current loop inside and other parts outside the active cells. Electrical potentials are created by the current loops, and are positive when these are approaching, negative when they are receding. In so doing they form the basis of all extracellular wave forms.
9 vídeos (total de (Total 44 mín.) min), 3 leituras, 1 teste
9 videos
Geometry6min
Left or right side stimulation5min
Simultaneous stimulation model2min
Definitions and questions6min
Origin in the membrane6min
Big loops as well as small4min
Approaching wave forms5min
Departing wave forms3min
Observations4min
3 leituras
Cylinderical Fiber Model Slides9min
Current Loops Slides10min
Current Loops and the Extracellular Waveforms Slides10min
1 exercício prático
224min
Semana
3Week 3
Notable and useful aspects of extracellular wave forms are their changes in shape. What causes such changes? Two illuminating examples are studied, one that does not, and then another that does.
7 vídeos (total de (Total 33 mín.) min), 3 leituras, 1 teste
7 videos
Vm and current inside3min
Vm patterns3min
Current loops3min
Experimental setup, cardiac Purkinje6min
Stimulation at the left or right3min
Stimulation at both ends, collision5min
3 leituras
When do Wave Shapes Change? Slides10min
Simultaneous Left and Right Stimulation Slides10min
Experimental Data Slides10min
1 exercício prático
324min
Semana
4Week 4
Weeks 1 to 3 present some intriguing concepts and explain them with drawings and sketches. Do the wave forms so drawn have any connection with real tissue? Indeed they do. The goal of this week is to examine some specific experimental wave forms that were measured in cardiac Punkinje fibers, and to compare them those anticipated in earlier weeks.Week 4 is the end of the standard course. The remaining weeks are for honors study.
4 vídeos (total de (Total 17 mín.) min), 1 leitura, 1 teste
4 videos
Two-fiber model, asynchronous2min
Experimental findings6min
Multiphasic summary3min
1 leituras
Multiphasic Recordings Slides10min
1 exercício prático
424min
4.6
9 avaliaçõesMelhores avaliações
por AJ•Apr 15th 2018
Great follow up course to the previous within the installment regarding bioelectricity. Taught me quite a lot and am looking forward to further releases to the series if they are in the works.
por PW•Mar 8th 2017
Having been out school for over 30 years this was a very challenging but rewarding course for myself. I'm glad i took it
Instrutores
Dr. Roger Barr
Anderson-Rupp Professor of Biomedical Engineering and Associate Professor of PediatricsBiomedical Engineering, Pediatrics
Sobre Universidade Duke
Duke University has about 13,000 undergraduate and graduate students and a world-class faculty helping to expand the frontiers of knowledge. The university has a strong commitment to applying knowledge in service to society, both near its North Carolina campus and around the world.
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