Informações sobre o curso
4.7
41 classificações
6 avaliações
100% online

100% online

Comece imediatamente e aprenda em seu próprio cronograma.
Prazos flexíveis

Prazos flexíveis

Redefinir os prazos de acordo com sua programação.
Nível intermediário

Nível intermediário

Horas para completar

Aprox. 19 horas para completar

Sugerido: 6 weeks of study, 3-5 hours a week...
Idiomas disponíveis

Inglês

Legendas: Inglês
100% online

100% online

Comece imediatamente e aprenda em seu próprio cronograma.
Prazos flexíveis

Prazos flexíveis

Redefinir os prazos de acordo com sua programação.
Nível intermediário

Nível intermediário

Horas para completar

Aprox. 19 horas para completar

Sugerido: 6 weeks of study, 3-5 hours a week...
Idiomas disponíveis

Inglês

Legendas: Inglês

Programa - O que você aprenderá com este curso

Semana
1
Horas para completar
3 horas para concluir

Introduction. Human genome

This week you will learn about human genome organisation. This week is very important as all this knowledge will form a basis for all of the subsequent weeks of the course. Michel Georges will tell you about the structural organisation of the human genome, the mechanisms contributing to the genome variability, the main types of genetic variation (SNPs, CNVs, aneuploidy, etc.), and differences between alleles and genotypes. You will also learn the techniques used to detect different types of variations in human genome and you will find out how we can follow the inheritance of genetic material through generations. ...
Reading
7 vídeos (total de (Total 54 mín.) min), 9 leituras, 9 testes
Video7 videos
Course Introduction1min
Anatomy of the Human Genome13min
Identifying Functionally Important Elements in the Human Reference Genome12min
Genetic Polymorphism11min
Interrogating Genetic Variation10min
Week 1 Conclusion2min
Reading9 leituras
Meet your Educators and Fellow Learners10min
Course Navigation10min
Typos in videos10min
Recommended Pre-reading10min
The Human Genome Project30min
Recommended Pre-reading10min
Recommended Pre-reading10min
Recommended Pre-reading10min
Glossary Week 110min
Quiz9 exercícios práticos
Pre-lecture Questions6min
Practice Quiz2min
Pre-lecture Questions4min
Practice Quiz2min
Pre-lecture Questions4min
Practice Quiz4min
Pre-lecture Questions6min
Practice Quiz2min
Introduction. Human Genome8min
Semana
2
Horas para completar
4 horas para concluir

Populational genetics

During this week, Yurii Aulchenko will teach you the basics of population and quantitative genetics. Population genetics is a branch of genetics that deals with genetic variation among individuals in a population. "Nothing in Biology Makes Sense Except in the Light of Evolution" is a quotation from a 1973 essay by the evolutionary biologist Theodosius Dobzhansky. The fundamental importance of population genetics lies in the insights it provides into the mechanisms of evolution, thus allowing geneticists to better understand the drivers behind the organization and functioning of human genomes. You will learn about such phenomena as population structure, selection and genetic drift. You will also learn about quantitative genetics, which studies how the genes and environment control variations in complex phenotypes....
Reading
7 vídeos (total de (Total 59 mín.) min), 13 leituras, 13 testes
Video7 videos
Hardy-Weinberg Equilibrium8min
Linkage Disequilibrium8min
Natural Selection11min
Genetic Drift9min
Genetic Structure12min
Week 2 Conclusion2min
Reading13 leituras
Recommended Pre-reading10min
Additional Materials10min
Recommended Pre-reading10min
Additional Materials10min
Recommended Pre-reading10min
Additional Materials10min
Recommended Pre-reading10min
Additional Materials10min
Recommended Pre-reading10min
Additional Materials10min
Recommended Pre-reading10min
Additional Materials10min
Glossary Week 210min
Quiz13 exercícios práticos
Pre-lecture Questions4min
Practice Quiz4min
Pre-lecture Questions6min
Practice Quiz4min
Pre-lecture Questions4min
Practice Quiz4min
Pre-lecture Questions4min
Practice Quiz2min
Pre-lecture Questions4min
Practice Quiz4min
Pre-lecture Questions2min
Practice Quiz4min
Populational Genetics14min
Semana
3
Horas para completar
3 horas para concluir

Mendelian disorders

Mendelian or monogenic disorders are the kind of genetic disorders in humans that arise from a mutation in a single gene. These disorders run in families and can be autosomal or sex-linked depending whether the affected gene is located on autosomes or sex chromosomes, and they can also be dominant or recessive depending if one or two alleles are necessary to develop the disorder. The name “Mendelian” is used because these diseases follow simple monogenic patterns of inheritance, similar to these first studied by Gregor Mendel in pea plants. There are an estimated 8000 rare Mendelian diseases. Although each of them are very rare, collectively they affect millions of individuals world-wide. How can we find the variants and genes that are responsible for the development of these diseases? You will learn about “linkage analysis” – a technique that has been previously used for this purpose. You will also learn about Next-generation sequencing (NGS) technologies that have revolutionized the studies of Mendelian diseases in recent years. ...
Reading
6 vídeos (total de (Total 51 mín.) min), 10 leituras, 11 testes
Video6 videos
Linkage Analysis. Family Studies11min
NGS for Studying Monogenic Disorders — Part I7min
NGS for Studying Monogenic Disorders — Part II10min
NGS for Studying Monogenic Disorders — Part III11min
Week 3 Conclusion1min
Reading10 leituras
Recommended Pre-reading10min
Additional Materials10min
Recommended Pre-reading10min
Additional Materials10min
Recommended Pre-reading10min
Additional Materials10min
Recommended Pre-reading10min
Additional Materials10min
Mendelian disorders: discussion10min
Glossary Week 310min
Quiz11 exercícios práticos
Pre-lecture Questions2min
Practice Quiz2min
Pre-lecture Questions2min
Practice Quiz2min
Pre-lecture Questions2min
Practice Quiz2min
Pre-lecture Questions4min
Practice Quiz2min
Pre-lecture Questions2min
Practice Quiz2min
Mendelian Disorders10min
Semana
4
Horas para completar
6 horas para concluir

Complex disorders

In contrast to Mendelian disorders that are controlled by a mutation in one gene, the multifactorial disorders are more complex, thus the name. These disorders are affected by an interplay of many genetic and environmental factors and also by a chance. Most of the human disorders, including prevalent types of diabetes, cardiovascular diseases, different cancers, are of such type. Although these disorders often cluster in families, they do not segregate in ways that are consistent with simple Mendelian inheritance. The methods used to find variants responsible for Mendelian disorders are not applicable for complex ones. Genome-wide association studies, or “GWAS” is a current method of choice to pinpoint the genetic variation predisposing to complex disorders. Yurii Aulchenko together with Lennart Karssen will tell you about this method and discuss its advantages and limitations. ...
Reading
10 vídeos (total de (Total 88 mín.) min), 18 leituras, 19 testes
Video10 videos
Introduction to Genome-Wide Association Studies. Historical Overview12min
GWAS Nowadays. Imputations10min
4.4. Analysis of Directly Genotyped and Imputed data. Significance of GWAS11min
4.5. Population Stratification and its Consequences10min
4.6. Analysis of Genetically Structured Populations9min
4.7. Meta-analysis of GWAS Results: Theory and Background6min
4.8. Quality Control of GWAS Array Data10min
4.9. Meta-analysis of GWAS Results: Practical Details8min
Week 4 Conclusion2min
Reading18 leituras
Recommended Pre-reading10min
Additional Materials10min
Recommended Pre-reading10min
Additional Materials10min
Recommended Pre-reading10min
Additional Materials10min
Recommended Pre-reading10min
Additional Materials10min
Recommended Pre-reading10min
Additional Materials10min
Recommended Pre-reading10min
Additional Materials10min
Recommended Pre-reading10min
Additional Materials10min
Recommended Pre-reading10min
Additional Materials10min
Additional Materials10min
Glossary Week 410min
Quiz19 exercícios práticos
Pre-lecture Questions4min
Practice Quiz4min
Pre-lecture Questions2min
Practice Quiz6min
Pre-lecture Questions2min
Practice Quiz2min
Pre-lecture Questions4min
Post-lecture Questions4min
Pre-lecture Questions2min
Post-lecture Questions4min
Pre-lecture Questions4min
Post-lecture Questions6min
Pre-lecture Questions2min
Post-lecture Questions4min
Pre-lecture Questions2min
Post-lecture Questions2min
Pre-lecture Questions2min
Quiz4min
Complex disorders26min
4.7
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Melhores avaliações

por FLSep 27th 2018

Highly recommended!\n\nAn interesting, up-to-date course with eye-catching and well designed videos.

por JQDec 30th 2017

Fun and interesting course. Great review of material I had forgotten, sadly.

Instrutores

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Marianna Bevova

PhD, Director of GIGA Doctoral School
University of Liège (GIGA)
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Michel Georges

PhD, Professor, GIGA Research Director
University of Liège
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Gert Matthijs

PhD, Professor
Center for Human Genetics, University of Leuven
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Lennart Karssen

PhD, Owner and Chief Computational Scientist
PolyOmica
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Natalia Aulchenko

M.Sc., Project manager
Theoretical and Applied Functional Genomics Laboratory
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Yakov Tsepilov

PhD, Senior Researcher
Theoretical and Applied Functional Genomics Laboratory
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Sodbo Sharapov

M.Sc, Junior Researcher
Theoretical and Applied Functional Genomics Laboratory
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Alexander Tashkeev

Skolkovo Institute of Science and Technology (Skoltech), Junior Researcher
Laboratory of Computational and Structural Transcriptomics
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Yurii Aulchenko

PhD, Professor, Head of Theoretical and Applied Functional Genomics Laboratory
Theoretical and Applied Functional Genomics Laboratory

Sobre Novosibirsk State University

Novosibirsk State University (NSU) is a research university located in Novosibirsk Akademgorodok, the world-famous scientific center in Siberia. 80% of NSU teachers are active researchers affiliated with the Russian Academy of Sciences; therefore education is closely linked to world-class science: our students get first-hand knowledge about scientific discoveries before they are published. Nearly 6000 students (including international students from 37 countries) are enrolled at undergraduate and graduate programs offered by 13 departments. The leading areas of NSU expertise are natural sciences, life sciences, physics, math, IT, and more....

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