SEMANA 1

WEEK 1

Introduction to 'chronobiology'. What sorts of rhythms are observed in nature? Most of the lecture will be spent on describing daily or circadian rhythms in organisms from bacteria to man.

9 videos, 1 leituras

Vídeo: 1.1 The Family of Biological Rhythms
Vídeo: 1.2 The Circa-Rhythms
Vídeo: 1.3 Spatial and Temporal Niches
Vídeo: 1.4 The Case of Gonyaulax polyedra
Vídeo: 1.5 Introduction to the Second Half of Lecture 1
Vídeo: 1.6 Circadian Rhythms in Mammals
Vídeo: 1.7 Circadian Clocks in Flies, Plants and Fungi
Vídeo: 1.8 Wrap up for Lecture 1
Reading: Literature suggestion

Nota atribuída: Lecture 1, Introduction, first half.

Nota atribuída: Lecture 1, Introduction, second half.

SEMANA 2

WEEK 2

Circadian rhythms synchronise to the 24-hour environment. Organisms use specialised photoreceptors to do this and they display characteristic properties in this process. We experience this active synchronisation process for example when we suffer from jet lag!

5 videos, 3 leituras

Vídeo: 2.1 Pittendrigh´s generalisations 1-9
Vídeo: 2.2 Pittendrigh´s generalisations 10 and 11
Vídeo: 2.3 Pittendrigh´s generalisations 12-16 and entrainment
Vídeo: 2.4 Wrap-up for Lecture 2
Reading: Literature suggestion
Reading: Translation of de Mairan's botanical observation
Reading: Obituary Jürgen Aschoff

Nota atribuída: Formalisms

SEMANA 3

WEEK 3

We will discuss the elaborate molecular mechanisms that allow circadian clocks to produce their daily rhythms and to synchronise them to its environment. We will compare these mechanisms in a wide range of organisms.

8 videos, 1 leituras

Vídeo: 3.1 The first clock gene
Vídeo: 3.2 The negative feedback hypothesis
Vídeo: 3.3 More clock genes -many more!
Vídeo: 3.4 Post transcriptional mechanisms and the clock
Vídeo: 3.5 Indications of a non-transcriptional clock
Vídeo: 3.6 Zeitgebers and the molecular clockwork
Vídeo: 3.7 Wrap-up to Lecture 3
Reading: Literature suggestion

Nota atribuída: Lecture 3 Molecular mechanisms

SEMANA 4

WEEK 4

Circadian clocks serve to orchestrate physiology and metabolism in a coordinated way over the course of the day. Therefore, practically all processes in an organism are regulated outputs of the clock. We'll discuss examples of these processes and ideas about how this circadian regulation works.

8 videos, 1 leituras

Vídeo: 4.1 Clock control: which processes in humans and how to measure them?
Vídeo: 4.2 Schwänzeltanz
Vídeo: 4.3 The SCN regulates the timing of physiology and behaviour
Vídeo: 4.4 Clock controlled genes (ccg´s)
Vídeo: 4.5 Clock regulation of behaviour: genetic mechanisms
Vídeo: 4.6 Clock regulation of other major regulatory systems
Vídeo: 4.7 Wrap-Up to Lecture 4
Reading: Literature suggestion

Nota atribuída: Lecture 4: Clock control

SEMANA 5

WEEK 5

With the appreciation of the clock’s global control, we proceed to discussing how much this temporal programme controls our lives from birth to death and how much we mistreat the circadian clock in modern life.

6 videos, 1 leituras

Vídeo: 5.1 Chronotypes
Vídeo: 5.2 What makes up Chronotypes?
Vídeo: 5.3 Linking chronotype and light entrainment
Vídeo: 5.4 How modern life styles affect sleep
Vídeo: 5.5 Wrap-up to Lecture 5
Reading: The link to the MCTQ

Nota atribuída: Human

SEMANA 6

WEEK 6

Finally, we will look at the clock’s relationship to pathology. What are the consequences of living against the clock, what happens if the clock ‘breaks’, and how can we use our knowledge about the circadian system in medical diagnosis and therapy.

11 videos, 1 teste para praticar

Vídeo: 6.1 What is normal and what not and why?
Vídeo: 6.2 The consequences of living against the clock
Vídeo: 6.3 Circadian changes and Pathologies - comorbidities or causal factors
Vídeo: 6.4 Introduction to the Second Half of Lecture 6
Vídeo: 6.5 Clock genes that can really mess up the timing of sleep
Vídeo: 6.6 The clock gene mutant mice are sick
Vídeo: 6.7 Chronopharmacology and chronochemotherapy
Vídeo: 6.8 The circadian clock is a fitness characteristic
Vídeo: 6.9 Wrap-up to Lecture 6
Vídeo: 6.10 Farewell from your CircaClock Team
Practice Quiz: Final Exam "Circaclock"
Peer Review: Peer-Reviewed Assignment

Nota atribuída: Pathology

Nota atribuída: Lecture 6. Clock and pathologies

Idioma	Inglês
Como ser aprovado	Seja aprovado em todas as tarefas para concluir o curso.

Circadian clocks: how rhythms structure life

Circadian clocks: how rhythms structure life