This course is geared towards starting undergraduate students. A solid background in biology will be helpful but not absolutely essential. The material will be of interest to those who are pursuing a career in any of the life sciences as well as anyone who has run up against their biological clock.
Ritmo circadianos: como o relógio biológico rege a vida
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Universidade Ludwig-Maximilians de Munique (LMU)
Programa - O que você aprenderá com este curso
Semana
12 horas para concluir
WEEK 1
Introduction to 'chronobiology'. What sorts of rhythms are observed in nature? Most of the lecture will be spent on describing daily or circadian rhythms in organisms from bacteria to man.
9 vídeos (total de (Total 62 mín.) min), 1 leitura, 2 testes
9 videos
1.1 The Family of Biological Rhythms 7min
1.2 The Circa-Rhythms5min
1.3 Spatial and Temporal Niches3min
1.4 The Case of Gonyaulax polyedra 6min
1.5 Introduction to the Second Half of Lecture 1 50s
1.6 Circadian Rhythms in Mammals 7min
1.7 Circadian Clocks in Flies, Plants and Fungi12min
1.8 Wrap up for Lecture 118min
1 leituras
Literature suggestion10min
2 exercícios práticos
Lecture 1, Introduction, first half.10min
Lecture 1, Introduction, second half.10min
Semana
21 hora para concluir
WEEK 2
Circadian rhythms synchronise to the 24-hour environment. Organisms use specialised photoreceptors to do this and they display characteristic properties in this process. We experience this active synchronisation process for example when we suffer from jet lag!
5 vídeos (total de (Total 46 mín.) min), 3 leituras, 1 teste
5 videos
2.1 Pittendrigh´s generalisations 1-9 17min
2.2 Pittendrigh´s generalisations 10 and 11 7min
2.3 Pittendrigh´s generalisations 12-16 and entrainment11min
2.4 Wrap-up for Lecture 28min
3 leituras
Literature suggestion10min
Translation of de Mairan's botanical observation5min
Obituary Jürgen Aschoff10min
1 exercício prático
Formalisms12min
Semana
31 hora para concluir
WEEK 3
We will discuss the elaborate molecular mechanisms that allow circadian clocks to produce their daily rhythms and to synchronise them to its environment. We will compare these mechanisms in a wide range of organisms.
8 vídeos (total de (Total 62 mín.) min), 1 leitura, 1 teste
8 videos
3.1 The first clock gene8min
3.2 The negative feedback hypothesis 15min
3.3 More clock genes -many more! 5min
3.4 Post transcriptional mechanisms and the clock 11min
3.5 Indications of a non-transcriptional clock 6min
3.6 Zeitgebers and the molecular clockwork9min
3.7 Wrap-up to Lecture 34min
1 leituras
Literature suggestion10min
1 exercício prático
Lecture 3 Molecular mechanisms12min
Semana
41 hora para concluir
WEEK 4
Circadian clocks serve to orchestrate physiology and metabolism in a coordinated way over the course of the day. Therefore, practically all processes in an organism are regulated outputs of the clock. We'll discuss examples of these processes and ideas about how this circadian regulation works.
8 vídeos (total de (Total 60 mín.) min), 1 leitura, 1 teste
8 videos
4.1 Clock control: which processes in humans and how to measure them? 10min
4.2 Schwänzeltanz 5min
4.3 The SCN regulates the timing of physiology and behaviour 3min
4.4 Clock controlled genes (ccg´s) 14min
4.5 Clock regulation of behaviour: genetic mechanisms 5min
4.6 Clock regulation of other major regulatory systems 4min
4.7 Wrap-Up to Lecture 414min
1 leituras
Literature suggestion10min
1 exercício prático
Lecture 4: Clock control10min
Semana
51 hora para concluir
WEEK 5
With the appreciation of the clock’s global control, we proceed to discussing how much this temporal programme controls our lives from birth to death and how much we mistreat the circadian clock in modern life.
6 vídeos (total de (Total 58 mín.) min), 1 leitura, 1 teste
6 videos
5.1 Chronotypes11min
5.2 What makes up Chronotypes?8min
5.3 Linking chronotype and light entrainment12min
5.4 How modern life styles affect sleep7min
5.5 Wrap-up to Lecture 516min
1 leituras
The link to the MCTQ10min
1 exercício prático
Human12min
Semana
65 horas para concluir
WEEK 6
Finally, we will look at the clock’s relationship to pathology. What are the consequences of living against the clock, what happens if the clock ‘breaks’, and how can we use our knowledge about the circadian system in medical diagnosis and therapy.
11 vídeos (total de (Total 77 mín.) min), 4 testes
11 videos
6.1 What is normal and what not and why? 9min
6.2 The consequences of living against the clock11min
6.3 Circadian changes and Pathologies - comorbidities or causal factors 3min
6.4 Introduction to the Second Half of Lecture 6 1min
6.5 Clock genes that can really mess up the timing of sleep8min
6.6 The clock gene mutant mice are sick 8min
6.7 Chronopharmacology and chronochemotherapy 4min
6.8 The circadian clock is a fitness characteristic8min
6.9 Wrap-up to Lecture 613min
6.10 Farewell from your CircaClock Team 6min
3 exercícios práticos
Final Exam "Circaclock"58min
Pathology8min
Lecture 6. Clock and pathologies8min
Instrutores
Martha Merrow
ProfessorMedical Psychology
Till Roenneberg
ProfessorMedical Psychology
Sobre Universidade Ludwig-Maximilians de Munique (LMU)
As one of Europe's leading research universities, LMU Munich is committed to the highest international standards of excellence in research and teaching. Building on its 500-year-tradition of scholarship, LMU covers a broad spectrum of disciplines, ranging from the humanities and cultural studies through law, economics and social studies to medicine and the sciences.
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