Over 500,000 people in the United States and over 8 million people worldwide are dying from cancer every year. As people live longer, the incidence of cancer is rising worldwide, and the disease is expected to strike over 20 million people annually by 2030.
Everyone has been, or will be touched by cancer in some way during their lifetime. Thanks to years of dedication and commitment to research we’ve made enormous advances in the prevention and treatment of cancer, But there is still a lot of work to be done.
In this course, physicians and scientists at the Johns Hopkins School of Medicine explain how cancer spreads or metastasizes. We’ll describe the major theories of metastasis and then describe the biology behind the steps in metastasis. The course also describes the major organs targeted by metastasis and describes how metastases harm the patient.
Understanding Cancer Metastasis
oferecido por
Johns Hopkins University
Informações sobre o curso
4.8
490 classificações
Habilidades que você terá
CancerMolecular BiologyCancer BiologyCancer Stem Cells
Programa - O que você aprenderá com este curso
Semana
1History and Overview of Metastasis
In this first module, we'll concentrate on the history and overview of metastasis and give you a flavor of how cancer is defined as well as some of the history surrounding how we began to understand metastasis.
5 vídeos (total de (Total 18 mín.) min), 1 teste
5 videos
Introduction to History and Overview of Metastasis48s
History and Overview of Metastasis4min
History of Metastasis Theory4min
Introduction to the Sequential Steps of Metastasis5min
1 exercícios práticos
History and Overview of Metastasis20min
Primary Tumor Growth and Neoangiogenesis
In this module, we'll focus on uncontrolled cell division, which is a defining property of cancer, as well as mutation and neoangiogenesis and their roles in tumor formation. We'll also take a look at a primary tumor microenvironment and its component cell types.
5 vídeos (total de (Total 36 mín.) min), 1 teste
5 videos
Tumor formation: Uncontrolled cell division12min
The role of mutations in primary tumor formation and evolution11min
Neoangiogenesis: new blood vessel formation in cancer5min
The primary tumor microenvironment: what else affects primary tumor growth?6min
1 exercícios práticos
Primary Tumor Growth and Neoangiogenesis24min
Semana
2EMT / Invasion / Intravasation
During this module, we'll turn our attention to the next steps after the initial primary tumor formation, epithelial to mesenchymal transition of cancer cells, and local tumor invasion and intravasation into blood or lymph vessels.
4 vídeos (total de (Total 18 mín.) min), 1 teste
4 videos
Epithelial-mesenchymal transition, invasion, and intravision9min
Local Tumor Invasion4min
Intravasation2min
1 exercícios práticos
Invasion and Intravasation14min
Survival in the Circulation and Extravasation
We'll now take a close look at cancer survival within the circulation, the role of the circulatory system in metastasis, the genetic determinants of metastatic potential, signalling mechanisms, chemokines, the dock and lock hypothesis, and extravasation.
6 vídeos (total de (Total 31 mín.) min), 1 teste
6 videos
Glossary of Terms2min
The Circulation4min
How cancer cells survive while in circulation4min
Becoming a circulating tumor cell (CTC) and evading immune detection10min
Homing to a new site in the body and extravasation8min
1 exercícios práticos
Survival in the Circulation and Extravasation24min
Semana
3Dormancy and Secondary Tumor Growth
In this module, we'll focus on dormancy and secondary tumor growth and how they contribute to the lethality of cancer.
6 vídeos (total de (Total 31 mín.) min), 1 teste
6 videos
Metastatic homing5min
Evidence for cancer dormancy4min
Cancer dormancy defined8min
Properties of dormant cancer cells6min
Secondary outgrowth4min
1 exercícios práticos
Dormancy and Secondary Tumor Growth20min
Morbidity and Mortality Associated with Metastasis
In the previous modules, we've looked closely at the sequential steps of metastasis and some of the biology of how metastasis occurs. Now, we'll turn our attention to morbidity and mortality, or in other words, how cancer hurts and kills people.
4 vídeos (total de (Total 27 mín.) min), 1 teste
4 videos
Distribution of Metastasis: Where do cancers spread?10min
Cancer Syndromes14min
Congratulations1min
1 exercícios práticos
Morbidity and Mortality Associated with Metastasis20min
Instrutores
Kenneth J. Pienta, M.D.
The Donald S. Coffey Professor of UrologyThe James Buchanan Brady Urological Institute
Jelani Zarif
Prostate Cancer ResearcherThe James Buchanan Brady Urological Institute
Sarah Amend
Prostate Cancer ResearcherThe James Buchanan Brady Urological Institute
Haley Axelrod
Prostate Cancer ResearcherThe James Buchanan Brady Urological Institute
Kenneth Valkenburg
Prostate Cancer ResearcherThe James Buchanan Brady Urological Institute
Sobre Johns Hopkins University
The mission of The Johns Hopkins University is to educate its students and cultivate their capacity for life-long learning, to foster independent and original research, and to bring the benefits of discovery to the world.
Perguntas Frequentes – FAQ
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