Informações sobre o curso
4.5
34 classificações
11 avaliações
100% online

100% online

Comece imediatamente e aprenda em seu próprio cronograma.
Prazos flexíveis

Prazos flexíveis

Redefinir os prazos de acordo com sua programação.
Nível intermediário

Nível intermediário

Horas para completar

Aprox. 23 horas para completar

Sugerido: 6 hours/week...
Idiomas disponíveis

Inglês

Legendas: Inglês
100% online

100% online

Comece imediatamente e aprenda em seu próprio cronograma.
Prazos flexíveis

Prazos flexíveis

Redefinir os prazos de acordo com sua programação.
Nível intermediário

Nível intermediário

Horas para completar

Aprox. 23 horas para completar

Sugerido: 6 hours/week...
Idiomas disponíveis

Inglês

Legendas: Inglês

Programa - O que você aprenderá com este curso

Semana
1
Horas para completar
3 horas para concluir

Electricity in Solutions

This week's theme focuses on the foundations of bioelectricity including electricity in solutions. The learning objectives for this week are: (1) Explain the conflict between Galvani and Volta; (2) Interpret the polarity of Vm in terms of voltages inside as compared to outside cells; (3) Interpret the polarity of Im in terms of current flow into or out of a cell.; (4) Determine the energy in Joules of an ordinary battery, given its specifications; (5) State the “big 5” electrical field variables (potentials, field, force, current, sources) and be able to compute potentials from sources (the basis of extracellular bioelectric measurements such as the electrocardiogram) or find sources from potentials....
Reading
12 vídeos (total de (Total 66 mín.) min), 5 leituras, 2 testes
Video12 videos
What is the Question5min
About Bioelectricity5min
Major Sections of the Course5min
Rectification of Names10min
Ions in Solution6min
Core-Conductor Model of a Nerve Fiber9min
Potential and Voltages in the Fiber5min
Axial Currents in the Fiber5min
Membrane Resistance3min
Membrane Current, Failure & Mystery3min
Week 1 in Review4min
Reading5 leituras
Welcome to the Courses
Assessments, Grading and Certificates10min
Course Lecture Slides10min
Discussion Forums10min
Reference Text10min
Quiz2 exercícios práticos
Quiz 1A10min
Quiz 1B16min
Semana
2
Horas para completar
2 horas para concluir

Energy into Voltage

This week we will examine energy, by which pumps and channels allow membranes to "charge their batteries" and thereby have a non-zero voltage across their membranes at rest. The learning objectives for this week are: (1) Describe the function of the sodium-potassium pump; (2) State from memory an approximate value for RT/F; (3) Be able to find the equilibrium potential from ionic concentrations and relative permeabilities; (4) Explain the mechanism by which membranes use salt water to create negative or positive trans-membrane voltages....
Reading
12 vídeos (total de (Total 76 mín.) min), 2 testes
Video12 videos
A Membrane Patch; the Idea of It7min
Energy as Trans-membrane Voltage Vm3min
Sodium-potassium Pumps4min
Ionic equilibrium13min
Battery lifetime5min
Problem session 14min
Membrane Resistance Rm9min
Membrane capacitance Cm4min
Why is Cm so big?7min
Problem session, R and C8min
Week 2 summary5min
Quiz2 exercícios práticos
Quiz 2A20min
Quiz 2B12min
Semana
3
Horas para completar
2 horas para concluir

Passive and Active Resonses, Channels

This week we'll be discussing channels and the remarkable experimental findings on how membranes allow ions to pass through specialized pores in the membrane wall. The learning objectives for this week are: (1) Describe the passive as compared to active responses to stimulation; (2) Describe the opening and closing of a channel in terms of probabilities; (3) Given the rate constants alpha and beta at a fixed Vm, determine the channel probabilities; (4) Compute how the channel probabilities change when voltage Vm changes....
Reading
12 vídeos (total de (Total 82 mín.) min), 1 leitura, 3 testes
Video12 videos
Why are passive and active so different?3min
The simulation set-up9min
The passive simulation11min
The active simulation11min
Where does the active response come from?8min
Problem session, passive v active6min
Channels: Experimental isolation of a channel7min
Channels: Observed currents, voltage step4min
Channels: Probability of being open6min
Problem session, Channel probabilities8min
Week 3 Conclusions4min
Reading1 leituras
Alpha Beta Programming Assignment Instructions10min
Quiz3 exercícios práticos
Quiz 3A12min
Quiz 3B18min
Alpha Beta Programming Assignment24min
Semana
4
Horas para completar
3 horas para concluir

Hodgkin-Huxley Membrane Models

This week we will examine the Hodgkin-Huxley model, the Nobel-prize winning set of ideas describing how membranes generate action potentials by sequentially allowing ions of sodium and potassium to flow. The learning objectives for this week are: (1) Describe the purpose of each of the 4 model levels 1. alpha/beta, 2. probabilities, 3. ionic currents and 4. trans-membrane voltage; (2) Estimate changes in each probability over a small interval $$\Delta t$$; (3) Compute the ionic current of potassium, sodium, and chloride from the state variables; (4) Estimate the change in trans-membrane potential over a short interval $$\Delta t$$; (5) State which ionic current is dominant during different phases of the action potential -- excitation, plateau, recovery....
Reading
12 vídeos (total de (Total 95 mín.) min), 1 leitura, 3 testes
Video12 videos
What is the Problem8min
HH replacement for Rm5min
The equation for each pathway10min
Changes in n, m, h11min
Equations for alphas and betas18min
Problem session, I_Na9min
Putting it all together6min
Changes in n, m, h, and Vm5min
Numerical calculations, time and space6min
Problem session, a Vm step4min
Week 4 conclusions5min
Reading1 leituras
Action Potential Programming Assignment10min
Quiz3 exercícios práticos
Quiz 4A16min
Quiz 4B20min
Action Potential Programming Assignment18min
4.5
11 avaliaçõesChevron Right

Melhores avaliações

por JRSep 25th 2016

Very clear expectations, and the lectures were spaced out nicely to cover material while not being overwhelming. Additionally, the analogies used to convey the principles were clever and helpful!

por AJJan 15th 2018

Interesting class which derived mathematical models that were, and are still used, to describe nerves.

Instrutores

Avatar

Dr. Roger Barr

Anderson-Rupp Professor of Biomedical Engineering and Associate Professor of Pediatrics
Biomedical Engineering, Pediatrics

Sobre Duke University

Duke University has about 13,000 undergraduate and graduate students and a world-class faculty helping to expand the frontiers of knowledge. The university has a strong commitment to applying knowledge in service to society, both near its North Carolina campus and around the world....

Perguntas Frequentes – FAQ

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  • Quando você adquire o Certificado, ganha acesso a todo o material do curso, incluindo avaliações com nota atribuída. Após concluir o curso, seu Certificado eletrônico será adicionado à sua página de Participações e você poderá imprimi-lo ou adicioná-lo ao seu perfil no LinkedIn. Se quiser apenas ler e assistir o conteúdo do curso, você poderá frequentá-lo como ouvinte sem custo.

  • No. Completion of a Coursera course does not earn you academic credit from Duke; therefore, Duke is not able to provide you with a university transcript. However, your electronic Certificate will be added to your Accomplishments page - from there, you can print your Certificate or add it to your LinkedIn profile.

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